Smad9 - SMAD family member 9 Gene

Also Known as MADH6; Madh8; Madh9; Smad8

Species: Mus musculus

Gene Type: protein coding
Gene ID: 55994

Summary

This gene encodes a member of a family of proteins that act as downstream effectors of the bone morphogenetic protein (BMP) signaling pathway. The encoded protein is phosphorylated by BMP receptors, which stimulates its binding to SMAD4 and translocation into the nucleus, where it functions as a regulator of transcription. Activity of this protein is important for embryonic development. Mutation of this gene results in defects in pulmonary vasculature. [provided by RefSeq, Mar 2013]

Smad9 Products (1)

mRNA Protein Name
NM_019483.5 NP_062356.3 mothers against decapentaplegic homolog 9

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11163184 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within BMP signaling pathway IDA
IDA: Inferred from direct assay
18590716 MGI
acts upstream of or within BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19224984 MGI
involved in BMP signaling pathway IGI
IGI: Inferred from genetic interaction
19252488 MGI
involved in SMAD protein signal transduction IGI
IGI: Inferred from genetic interaction
19252488 MGI
acts upstream of or within bone development IGI
IGI: Inferred from genetic interaction
19224984 MGI
acts upstream of or within cartilage development IGI
IGI: Inferred from genetic interaction
19224984 MGI
acts upstream of or within cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
19103752 MGI
acts upstream of or within hindbrain development IMP
IMP: Inferred from mutant phenotype
15899870 MGI
acts upstream of or within midbrain development IMP
IMP: Inferred from mutant phenotype
15899870 MGI
acts upstream of or within protein phosphorylation IDA
IDA: Inferred from direct assay
18776146 MGI
involved in ureteric bud development IEP
IEP: Inferred from expression pattern
14656760 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19103752 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18776146 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mothers against decapentaplegic homolog 9

  • MAD homolog 9

  • mothers against DPP homolog 9

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13399 SMAD9 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19036 Smad9 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25525 Smad9 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smad9 NCBI NCBI:4093