Mad2l1 - MAD2 mitotic arrest deficient-like 1 Gene

Also Known as MAD2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56150

Summary

Predicted to enable protein C-terminus binding activity and protein homodimerization activity. Involved in negative regulation of apoptotic process and positive regulation of mitotic cell cycle spindle assembly checkpoint. Acts upstream of or within mitotic sister chromatid segregation and mitotic spindle assembly checkpoint signaling. Located in several cellular components, including kinetochore; nucleus; and spindle pole. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human MAD2L1 (mitotic arrest deficient 2 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Mad2l1 Products (2)

mRNA Protein Name
NM_001355624.1 NP_001342553.1 mitotic spindle assembly checkpoint protein MAD2A
NM_019499.5 NP_062372.2 mitotic spindle assembly checkpoint protein MAD2A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21666598 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within mitotic sister chromatid segregation IMP
IMP: Inferred from mutant phenotype
10892650 MGI
acts upstream of or within mitotic spindle assembly checkpoint signaling IMP
IMP: Inferred from mutant phenotype
11201745 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20870947 MGI
involved in positive regulation of mitotic cell cycle spindle assembly checkpoint IMP
IMP: Inferred from mutant phenotype
20870947 MGI
Cellular Component GO Annotation Evidence References Source
located in chromosome IDA
IDA: Inferred from direct assay
17325031 MGI
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
12355205 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
17504913 MGI
located in kinetochore IDA
IDA: Inferred from direct assay
10964468 MGI
part of mitotic spindle assembly checkpoint MAD1-MAD2 complex IPI
IPI: Inferred from physical interaction
12006501 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26919979 MGI
located in spindle pole IDA
IDA: Inferred from direct assay
10964468 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

mitotic spindle assembly checkpoint protein MAD2A

  • MAD2 (mitotic arrest deficient, homolog)-like 1

  • MAD2-like protein 1

  • mitotic arrest deficient 2-like protein 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07949 MAD2L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS07950 MAD2L1BP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20566 Mad2l1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27075 Mad2l1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mad2l1 NCBI NCBI:4085