MEPCE - methylphosphate capping enzyme Gene

Also Known as BCDIN3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56257

About MEPCE

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:100,428,790-100,434,118 (from NCBI)

This gene has 7 transcripts (splice variants), 196 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 29.4), spleen (RPKM 17.1) and 25 other tissues.

Summary

Enables 7SK snRNA binding activity and RNA 5'-methyltransferase activity. Involved in RNA modification; positive regulation of protein localization to Cajal body; and positive regulation of snRNA transcription by RNA polymerase II. Located in nucleus. Part of 7SK snRNP. [provided by Alliance of Genome Resources, Apr 2022]

MEPCE Products (5)

mRNA Protein Name
NM_001194990.2 NP_001181919.1 7SK snRNA methylphosphate capping enzyme isoform B
NM_001194991.2 NP_001181920.1 7SK snRNA methylphosphate capping enzyme isoform B
NM_001194992.2 NP_001181921.1 7SK snRNA methylphosphate capping enzyme isoform B
NM_001363486.2 NP_001350415.1 7SK snRNA methylphosphate capping enzyme isoform B
NM_019606.6 NP_062552.2 7SK snRNA methylphosphate capping enzyme isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 7SK snRNA binding IDA
IDA: Inferred from direct assay
28431135 GOA
enables RNA 5'-gamma-phosphate methyltransferase activity IDA
IDA: Inferred from direct assay
19906723 GOA
enables RNA binding IPI
IPI: Inferred from physical interaction
30559425 GOA
enables RNA methyltransferase activity IDA
IDA: Inferred from direct assay
17643375 GOA
enables RNA methyltransferase activity IMP
IMP: Inferred from mutant phenotype
24360279 GOA
enables S-adenosylmethionine-dependent methyltransferase activity IDA
IDA: Inferred from direct assay
17643375 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30824372 GOA
Biological Process GO Annotation Evidence References Source
involved in RNA methylation IDA
IDA: Inferred from direct assay
17643375 GOA
involved in positive regulation of protein localization to Cajal body IDA
IDA: Inferred from direct assay
28254838 GOA
involved in positive regulation of snRNA transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
28254838 GOA
involved in snRNA metabolic process IDA
IDA: Inferred from direct assay
17643375 GOA
involved in snRNA modification IDA
IDA: Inferred from direct assay
17643375 GOA
Cellular Component GO Annotation Evidence References Source
part of 7SK snRNP IDA
IDA: Inferred from direct assay
17643375 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19906723 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
19906723 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MEPCE Protein Structure

Bin3

Bin3: Bicoid-interacting protein 3 (Bin3) (574 - 683)

  • 0
  • 200
  • 400
  • 600
  • 689 a.a.
Protein Preferred Names Protein Names

7SK snRNA methylphosphate capping enzyme

  • bicoid-interacting protein 3 homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08338 MEPCE Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MEPCE MGD MGI:106477
Bos taurus MEPCE VGNC VGNC:106819
Canis familiaris MEPCE VGNC VGNC:43161
Rattus norvegicus MEPCE RGD RGD:1560550
Macaca mulatta MEPCE VGNC VGNC:74541
Felis catus MEPCE VGNC VGNC:63450
Others MEPCE NCBI