Tmed2 - transmembrane p24 trafficking protein 2 Gene

Also Known as Rnp24; Sid394; p24beta1; 1110032D12Rik; 1810020N21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56334

Summary

Involved in embryonic morphogenesis; labyrinthine layer blood vessel development; and maternal placenta development. Acts upstream of or within several processes, including PERK-mediated unfolded protein response; chordate embryonic development; and regulation of gene expression. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including cardiovascular system; early conceptus; embryo ectoderm; placenta; and trunk mesenchyme. Orthologous to human TMED2 (transmembrane p24 trafficking protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Tmed2 Products (6)

mRNA Protein Name
NM_001403253.1 NP_001390182.1 transmembrane emp24 domain-containing protein 2 isoform 1 precursor
NM_001403257.1 NP_001390186.1 transmembrane emp24 domain-containing protein 2 isoform 3
NM_019770.3 NP_062744.1 transmembrane emp24 domain-containing protein 2 isoform 2 precursor
NM_001403253.1 NP_001390182.1 transmembrane emp24 domain-containing protein 2 isoform 1 precursor
NM_001403257.1 NP_001390186.1 transmembrane emp24 domain-containing protein 2 isoform 3
NM_019770.3 NP_062744.1 transmembrane emp24 domain-containing protein 2 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables frizzled binding IPI
IPI: Inferred from physical interaction
35353806 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
31040128 MGI
enables smoothened binding IPI
IPI: Inferred from physical interaction
35353806 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within PERK-mediated unfolded protein response IMP
IMP: Inferred from mutant phenotype
28797121 MGI
acts upstream of or within allantois development IMP
IMP: Inferred from mutant phenotype
30236446 MGI
acts upstream of or within branching involved in labyrinthine layer morphogenesis IMP
IMP: Inferred from mutant phenotype
30236446 MGI
acts upstream of or within chorion development IMP
IMP: Inferred from mutant phenotype
30236446 MGI
involved in embryonic morphogenesis IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within embryonic placenta development IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within endoplasmic reticulum membrane organization IMP
IMP: Inferred from mutant phenotype
28797121 MGI
acts upstream of or within endoplasmic reticulum organization IMP
IMP: Inferred from mutant phenotype
30236446 MGI
acts upstream of or within heart looping IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within inflammatory response IMP
IMP: Inferred from mutant phenotype
31040128 MGI
involved in labyrinthine layer blood vessel development IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within maintenance of protein localization in organelle IMP
IMP: Inferred from mutant phenotype
35353806 MGI
involved in maternal placenta development IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within multicellular organism growth IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IMP
IMP: Inferred from mutant phenotype
28797121 MGI
acts upstream of or within negative regulation of protein localization to plasma membrane IMP
IMP: Inferred from mutant phenotype
35353806 MGI
acts upstream of or within negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
35353806 MGI
acts upstream of or within neural tube closure IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within post-anal tail morphogenesis IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
30236446 MGI
acts upstream of or within protein secretion IMP
IMP: Inferred from mutant phenotype
31040128 MGI
acts upstream of or within regulation of SREBP signaling pathway IMP
IMP: Inferred from mutant phenotype
28797121 MGI
acts upstream of or within somite rostral/caudal axis specification IMP
IMP: Inferred from mutant phenotype
20178780 MGI
acts upstream of or within somitogenesis IMP
IMP: Inferred from mutant phenotype
20178780 MGI
Cellular Component GO Annotation Evidence References Source
is active in Golgi apparatus IDA
IDA: Inferred from direct assay
35353806 MGI
located in Golgi apparatus IDA
IDA: Inferred from direct assay
35353806 MGI
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
30236446 MGI
located in endoplasmic reticulum-Golgi intermediate compartment IDA
IDA: Inferred from direct assay
30236446 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transmembrane emp24 domain-containing protein 2

  • COPI-coated vesicle membrane protein p24

  • Sid394p

  • coated vesicle membrane protein

  • membrane protein p24A

  • p24 family protein beta-1

  • sid 394

  • transmembrane emp24 domain trafficking protein 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14636 TMED2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21788 Tmed2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tmed2 NCBI NCBI:10959