Pus1 - pseudouridine synthase 1 Gene

Also Known as MPUS1; mPus1p; A730013B20Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56361

Summary

Enables chromatin binding activity; nuclear receptor coactivator activity; and tRNA pseudouridine synthase activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II and tRNA pseudouridine synthesis. Located in nucleolus. Part of transcription regulator complex. Used to study myopathy, lactic acidosis, and sideroblastic anemia. Human ortholog(s) of this gene implicated in myopathy, lactic acidosis, and sideroblastic anemia 1. Orthologous to human PUS1 (pseudouridine synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Pus1 Products (6)

mRNA Protein Name
NM_001025561.3 NP_001020732.1 pseudouridylate synthase 1 homolog isoform 1
NM_001025562.2 NP_001020733.1 pseudouridylate synthase 1 homolog isoform 3
NM_001347390.1 NP_001334319.1 pseudouridylate synthase 1 homolog isoform 4
NM_001359218.1 NP_001346147.1 pseudouridylate synthase 1 homolog isoform 5
NM_001359219.1 NP_001346148.1 pseudouridylate synthase 1 homolog isoform 3
NM_019700.4 NP_062674.2 pseudouridylate synthase 1 homolog isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables chromatin binding IDA
IDA: Inferred from direct assay
15327771 MGI
enables nuclear receptor coactivator activity IDA
IDA: Inferred from direct assay
15327771 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15327771 MGI
enables pseudouridine synthase activity IDA
IDA: Inferred from direct assay
11027153 MGI
enables pseudouridine synthase activity IMP
IMP: Inferred from mutant phenotype
15327771 MGI
enables tRNA pseudouridine synthase activity IDA
IDA: Inferred from direct assay
10094309 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15327771 MGI
acts upstream of or within tRNA pseudouridine synthesis IDA
IDA: Inferred from direct assay
11027153 MGI
involved in tRNA pseudouridine synthesis IDA
IDA: Inferred from direct assay
10094309 MGI
involved in tRNA pseudouridine synthesis IMP
IMP: Inferred from mutant phenotype
27197761 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
15327771 MGI
is active in nucleus IDA
IDA: Inferred from direct assay
15327771 MGI
located in nucleus IDA
IDA: Inferred from direct assay
15327771 MGI
part of transcription regulator complex IDA
IDA: Inferred from direct assay
15327771 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

pseudouridylate synthase 1 homolog

tRNA pseudouridine synthase A

  • tRNA pseudouridine synthase 1

  • tRNA pseudouridine synthase A, mitochondrial

  • tRNA pseudouridine(38-40) synthase

  • tRNA pseudouridylate synthase I

  • tRNA-uridine isomerase I

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N2456 Mogroside IV-E Inhibitor 99.71% Unkown
HY-RS11467 PUS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20804 Pus1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27318 Pus1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pus1 NCBI NCBI:80324