TMPRSS15 - transmembrane serine protease 15 Gene

Also Known as ENTK; PRSS7

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5651

About TMPRSS15

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:18,269,116-18,460,676 (from NCBI)

This gene has 3 transcripts (splice variants), 146 orthologues, 17 paralogues and is associated with 2 phenotypes. Restricted expression toward duodenum (RPKM 404.7).

Summary

This gene encodes an enzyme that converts the pancreatic proenzyme trypsinogen to trypsin, which activates Other proenzymes including chymotrypsinogen and procarboxypeptidases. The precursor protein is cleaved into two chains that form a heterodimer linked by a disulfide bond. This protein is a member of the trypsin family of peptidases. Mutations in this gene cause enterokinase deficiency, a malabsorption disorder characterized by diarrhea and failure to thrive. [provided by RefSeq, Jul 2008]

TMPRSS15 Products (1)

mRNA Protein Name
NM_002772.3 NP_002763.3 enteropeptidase precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
24407287 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMPRSS15 Protein Structure

SEA

SEA: SEA domain (58 - 157)

CUB

CUB: CUB domain (225 - 331)

MAM

MAM: MAM domain, meprin/A5/mu (347 - 503)

CUB

CUB: CUB domain (524 - 631)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (642 - 677)

SRCR_2

SRCR_2: Scavenger receptor cysteine-rich domain (695 - 774)

Trypsin

Trypsin: Trypsin (785 - 1014)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1019 a.a.
Protein Preferred Names Protein Names

enteropeptidase

  • enterokinase catalytic subunit

Related Diseases

Diseases Alias
Enterokinase Deficiency

  • Enteropeptidase Deficiency

  • Congenital Enterokinase Deficiency

  • Congenital Enteropathy Due To Enteropeptidase Deficiency

  • Deficiency Of Enteropeptidase

  • ENTKD
Diarrhea

  • Diarrhoea

  • Diarrhea Of Presumed Infectious Origin
Acute Pancreatitis

  • Pancreatitis

  • Pancreatitis, Acute Necrotizing

  • Pancreatitis Nos

  • Acute Pancreas Inflammation
Pancreatitis

  • Mumps Pancreatitis
Noonan Syndrome 8

  • NS8

  • Noonan Syndrome, Type 8
Hymenolepiasis

  • Dwarf Tapeworm Infection

  • Hymenolepis Infectious Disease

  • Hymenolepsis Infection

  • Hyemolepis Nana Infection

  • Hymenolepiosis

  • Hymenolepis Infection

  • Dwarf Tapeworm

  • Hymenolepidosis

  • Hymenolepis Infestation
Pancreas Disease

  • Abnormality Of The Pancreas

  • Pancreatic Diseases
Ciliary Dyskinesia, Primary, 26

  • Primary Ciliary Dyskinesia 26

  • CILD26

  • Primary Ciliary Dyskinesia 26 With Or Without Situs Inversus

  • Ciliary Dyskinesia, Primary, 26, With Or Without Situs Inversus

  • Dyskinesia, Ciliary, Primary, 26
Developmental And Epileptic Encephalopathy 53

  • DEE53

  • Epileptic Encephalopathy, Early Infantile, 53

  • Eiee53

  • Developmental And Epileptic Encephalopathy, 53

  • Early Infantile Epileptic Encephalopathy 53
Acute Necrotizing Pancreatitis

  • Pancreatitis, Acute Necrotizing
Psoriasis 11

  • PSORS11

  • Psoriasis Susceptibility 11

  • Psoriasis

  • Psoriasis Vulgaris

  • Psoriasis 11, Susceptibility To

  • Pv
Acute Hemorrhagic Pancreatitis

  • Pancreatitis, Acute Hemorrhagic
Lactase Deficiency, Congenital

  • Congenital Lactase Deficiency

  • Disaccharide Intolerance Ii

  • Congenital Alactasia

  • Congenital Alactasia Syndrome

  • Congenital Lactose Intolerance

  • Congenital Lactose Malabsorption

  • Hereditary Alactasia

  • Alactasia, Congenital

  • Cld

  • COLACD

  • Disaccharide Intolerance Type 2

  • Cld - [Congenital Lactase Deficiency]

  • Disaccharide Intolerance 2

  • Lactose Intolerance Of Newborn

  • Hereditary Lactase Deficiency
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P2990 Enteropeptidase / Unkown
HY-RS14768 TMPRSS15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21279 Tmprss15 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27798 Tmprss15 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TMPRSS15 VGNC VGNC:36139
Canis familiaris TMPRSS15 VGNC VGNC:47632
Macaca mulatta TMPRSS15 VGNC VGNC:108449
Rattus norvegicus TMPRSS15 RGD RGD:1311046
Mus musculus TMPRSS15 MGD MGI:1197523
Felis catus TMPRSS15 VGNC VGNC:69091
Others TMPRSS15 NCBI