Kcnd3 - potassium voltage-gated channel, Shal-related family, member 3 Gene

Also Known as Kncd3; Kv4.3

Species: Mus musculus

Gene Type: protein coding
Gene ID: 56543

Summary

Enables voltage-gated Potassium Channel activity involved in cardiac muscle cell action potential repolarization. Acts upstream of or within cardiac conduction; cardiac muscle cell action potential involved in contraction; and potassium ion export across plasma membrane. Located in membrane. Is integral component of postsynaptic specialization membrane. Is active in GABA-ergic synapse. Is expressed in heart and heart ventricle. Human ortholog(s) of this gene implicated in Brugada syndrome 9 and spinocerebellar ataxia type 19/22. Orthologous to human KCND3 (potassium voltage-gated channel subfamily D member 3). [provided by Alliance of Genome Resources, Apr 2022]

Kcnd3 Products (2)

mRNA Protein Name
NM_001039347.2 NP_001034436.1 potassium voltage-gated channel subfamily D member 3 isoform 1 precursor
NM_019931.2 NP_064315.1 potassium voltage-gated channel subfamily D member 3 isoform 2 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15662035 MGI
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
17122053 MGI
located in membrane IDA
IDA: Inferred from direct assay
18603586 MGI
is active in postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
17122053 MGI
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
8831489 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily D member 3

  • potassium channel Kv4.3L

  • potassium channel Kv4.3M

  • voltage-gated potassium channel subunit Kv4.3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07114 KCND3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20972 Kcnd3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27489 Kcnd3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnd3 NCBI NCBI:3752