PSG2 - pregnancy specific beta-1-glycoprotein 2 Gene

Also Known as CEA; PSG1; PSBG2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5670

About PSG2

Cytogenetic location: 19q13.31 Genomic coordinates (GRCh38): 19:43,064,209-43,082,701 (from NCBI)

This gene has 4 transcripts (splice variants), 627 orthologues and 24 paralogues. Restricted expression toward placenta (RPKM 263.6).

Summary

The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]

PSG2 Products (1)

mRNA	Protein	Name
NM_031246.4	NP_112536.2	pregnancy-specific beta-1-glycoprotein 2 precursor

PSG2 Protein Structure

V-set

Ig_2

0
100
200
300
335 a.a.

Protein Preferred Names	Protein Names
pregnancy-specific beta-1-glycoprotein 2	PS-beta-E

Recombinant PSG2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71106	PSG2 Protein, Human (HEK293, His)	P11465 (Q35-T335)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Secretory Meningioma	Meningioma
Cardiomyopathy, Dilated, 1x	Dilated Cardiomyopathy 1x CMD1X Dilated Cardiomyopathy With Mild Or No Proximal Muscle Weakness Cardiomyopathy, Dilated, With Mild Or No Proximal Muscle Weakness Cardiomyopathy, Dilated 1x Cardiomyopathy, Dilated, Type 1x
Obstructive Jaundice	Jaundice, Obstructive Cholestatic Jaundice Cholestatic Jaundice Syndrome Obstructive Hyperbilirubinemia Jaundice Obstructive Jaundice Cholestatic
Pericarditis
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Fiedler'S Myocarditis	Isolated Myocarditis Fiedler Myocarditis Idiopathic Myocarditis
Pleural Tuberculosis	Pearly Disease Tuberculosis Of Pleura Tuberculous Pleurisy Tuberculous Pleurisy In Primary Progressive Tuberculosis Tuberculous Pleuritis Pleurisy Tuberculous Tuberculosis, Pleural Serosal Tuberculosis Of Cattle
Thyroid Carcinoma, Familial Medullary	Medullary Thyroid Carcinoma Familial Medullary Thyroid Carcinoma MTC Medullary Thyroid Cancer Fmtc Mtc1 Thyroid Cancer, Medullary Thyroid Carcinoma, Medullary Familial Mtc Thyroid Carcinoma Medullary Carcinoma, Thyroid, Medullary, Familial Medullary Carcinoma Of Thyroid Medullary Carcinoma With Amyloid Stroma, Unspecified Site Medullary Carcinoma With Amyloid Stroma Of Thyroid
Central Sleep Apnea	Central Sleep Apnea Syndrome Sleep Apnea, Central Primary Central Sleep Apnea Central Sleep Apnea, Primary Central Sleep Apnoea Syndrome Csa - [Central Sleep Apnoea] Csas - [Central Sleep Apnoea Syndrome] Central Sleep Apnoea Due To Substances Including Medications
Twin-To-Twin Transfusion Syndrome	Twin To Twin Transfusion Syndrome Twin Twin Transfusion Syndrome Fetal Blood Loss From Fetal Hemorrhage Into Co-Twin Fetal Hemorrhage Into Co-Twin Twin To Twin Transfusion Twin-To-Twin Blood Transfer Fetal Transfusion Syndrome Fetofetal Transfusion Syndrome Ttts Feto-Fetal Transfusion Syndrome Fetofetal Transfusion Fetus-To-Fetus Placental Transfusion Syndrome
Microinvasive Gastric Cancer	Early Gastric Cancer Surface Gastric Cancer
Gastric Cancer	Stomach Cancer Gastric Carcinoma Stomach Carcinoma Gastric Cancer, Somatic Gastric Neoplasm Carcinoma Of Stomach Stomach Neoplasms Malignant Neoplasm Of Stomach Gastric Cancer Risk After H. Pylori Infection Cancer Of The Stomach Adult Stomach Cancer Adult Stomach Carcinoma GASC Gastric Cancer Intestinal Gastric Cancers Gastric Carcinomas Cancer, Gastric Stomach Neoplasm Malignant Neoplasm Of Body Of Stomach Malignant Tumor Of Lesser Curve Of Stomach Gastrocarcinoma Of Unspecified Site Leather Bottle Stomach Carcinoma Of Fundus Of Stomach Cancer Of Fundus Of Stomach Primary Malignant Neoplasm Of Body Of Stomach Cancer Of Body Of Stomach Primary Malignant Neoplasm Of Pyloric Antrum Pyloric Antrum Cancer Malignant Tumour Of Stomach
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11281	PSG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown