Rec8 - REC8 meiotic recombination protein Gene

Also Known as mrec; Rec8L1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 56739

Summary

Predicted to enable chromatin binding activity. Acts upstream of or within several processes, including gamete generation; seminiferous tubule development; and synaptonemal complex assembly. Located in kinetochore; lateral element; and male germ cell nucleus. Part of nuclear meiotic cohesin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human REC8 (REC8 meiotic recombination protein). [provided by Alliance of Genome Resources, Apr 2022]

Rec8 Products (3)

mRNA	Protein	Name
NM_001360389.1	NP_001347318.1	meiotic recombination protein REC8 homolog isoform 2
NM_001360390.1	NP_001347319.1	meiotic recombination protein REC8 homolog isoform 3
NM_020002.3	NP_064386.2	meiotic recombination protein REC8 homolog isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12759374	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within double-strand break repair via homologous recombination	IGI IGI: Inferred from genetic interaction	22711701	MGI
acts upstream of or within fertilization	IMP IMP: Inferred from mutant phenotype	22711701	MGI
acts upstream of or within homologous chromosome pairing at meiosis	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within male meiosis I	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within meiotic cell cycle	IPI IPI: Inferred from physical interaction	12759374	MGI
acts upstream of or within oocyte maturation	IGI IGI: Inferred from genetic interaction	17696610	MGI
acts upstream of or within oocyte maturation	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within seminiferous tubule development	IGI IGI: Inferred from genetic interaction	22711701	MGI
acts upstream of or within spermatid development	IMP IMP: Inferred from mutant phenotype	17696610	MGI
acts upstream of or within synaptonemal complex assembly	IGI IGI: Inferred from genetic interaction	22711701	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in condensed chromosome	IDA IDA: Inferred from direct assay	21795393	MGI
located in condensed chromosome, centromeric region	IDA IDA: Inferred from direct assay	18084284	MGI
located in condensed nuclear chromosome	IDA IDA: Inferred from direct assay	18084284	MGI
located in kinetochore	IDA IDA: Inferred from direct assay	18765791	MGI
located in lateral element	IDA IDA: Inferred from direct assay	15870106	MGI
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	17696610	MGI
part of meiotic cohesin complex	IDA IDA: Inferred from direct assay	17696610	MGI
located in nucleus	IDA IDA: Inferred from direct assay	12759374	MGI
located in synaptonemal complex	IDA IDA: Inferred from direct assay	12759374	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
meiotic recombination protein REC8 homolog	REC8-like 1 cohesin Rec8p meiotic cohesion Rec8

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11808	REC8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21419	Rec8 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27938	Rec8 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rec8	NCBI	NCBI:9985