KCMF1 - potassium channel modulatory factor 1 Gene

Also Known as FIGC; PCMF; ZZZ1; DEBT91

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56888

About KCMF1

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:84,971,161-85,059,472 (from NCBI)

This gene has 4 transcripts (splice variants) and 231 orthologues. Ubiquitous expression in testis (RPKM 9.7), thyroid (RPKM 7.1) and 25 other tissues.

Summary

Enables ubiquitin protein Ligase activity. Predicted to be involved in synaptic signaling. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

KCMF1 Products (1)

mRNA Protein Name
NM_020122.5 NP_064507.3 E3 ubiquitin-protein ligase KCMF1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
15581609 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of HRI-mediated signaling IDA
IDA: Inferred from direct assay
38297121 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
37891180 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
38297121 GOA
involved in protein K63-linked ubiquitination IDA
IDA: Inferred from direct assay
34893540 GOA
involved in response to oxidative stress IDA
IDA: Inferred from direct assay
34893540 GOA
involved in ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
34893540 GOA
Cellular Component GO Annotation Evidence References Source
is active in cytoplasm IDA
IDA: Inferred from direct assay
38297121 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCMF1 Protein Structure

ZZ

ZZ: Zinc finger, ZZ type (4 - 47)

zf-Di19

zf-Di19: Drought induced 19 protein (Di19), zinc-binding (76 - 137)

  • 0
  • 100
  • 200
  • 300
  • 381 a.a.
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase KCMF1

  • FGF-induced in gastric cancer

Related Diseases

Diseases Alias
Epidermodysplasia Verruciformis 1

  • Epidermodysplasia Verruciformis

  • Epidermodysplasia Verruciformis, Susceptibility To, 1

  • Lutz-Lewandowsky Epidermodysplasia Verruciformis

  • EV1

  • Lewandowsky-Lutz Syndrome

  • Ev
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07096 KCMF1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21607 Kcmf1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28125 Kcmf1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus KCMF1 RGD RGD:1591490
Mus musculus KCMF1 MGD MGI:1921537
Bos taurus KCMF1 VGNC VGNC:30419
Macaca mulatta KCMF1 VGNC VGNC:73868
Canis familiaris KCMF1 VGNC VGNC:58310
Others KCMF1 NCBI