TWSG1 - twisted gastrulation BMP signaling modulator 1 Gene

Also Known as TSG

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57045

About TWSG1

Cytogenetic location: 18p11.22 Genomic coordinates (GRCh38): 18:9,334,773-9,402,420 (from NCBI)

This gene has 3 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in endometrium (RPKM 35.8), gall bladder (RPKM 26.4) and 24 other tissues.

Summary

Enables transforming growth factor beta binding activity. Involved in several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of pathway-restricted SMAD protein phosphorylation; and transforming growth factor beta receptor signaling pathway. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TWSG1 Products (1)

mRNA Protein Name
NM_020648.6 NP_065699.1 twisted gastrulation protein homolog 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
enables transforming growth factor beta binding IDA
IDA: Inferred from direct assay
17164348 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of CD4-positive, alpha-beta T cell activation IDA
IDA: Inferred from direct assay
17164348 GOA
involved in negative regulation of CD4-positive, alpha-beta T cell proliferation IDA
IDA: Inferred from direct assay
17164348 GOA
involved in negative regulation of cytokine production IDA
IDA: Inferred from direct assay
17164348 GOA
involved in positive regulation of SMAD protein signal transduction IDA
IDA: Inferred from direct assay
17164348 GOA
involved in positive regulation of transforming growth factor beta receptor signaling pathway IDA
IDA: Inferred from direct assay
17164348 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TWSG1 Protein Structure

Tsg

Tsg: Twisted gastrulation (Tsg) protein conserved region (86 - 222)

  • 0
  • 100
  • 200
  • 223 a.a.
Protein Preferred Names Protein Names

twisted gastrulation protein homolog 1

  • twisted gastrulation homolog 1

TWSG1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TWSG1 Q9GZX9 FNDC9 Homo sapiens Q8TBE3
Y2H Prey Pooling
32296183
Intra
TWSG1 Q9GZX9 FNDC9 Homo sapiens Q8TBE3
Y2H Array
32296183
Intra
TWSG1 Q9GZX9 GPRC5D Homo sapiens Q9NZD1
Y2H Prey Pooling
32296183
Intra
TWSG1 Q9GZX9 GPRC5D Homo sapiens Q9NZD1
Validated Y2H
32296183
Intra
TWSG1 Q9GZX9 GPRC5D Homo sapiens Q9NZD1
Y2H Array
32296183
Intra
TWSG1 Q9GZX9 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
Intra
TWSG1 Q9GZX9 GJA8 Homo sapiens P48165
Y2H Array
32296183
Intra
TWSG1 Q9GZX9 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
TWSG1 Q9GZX9 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
TWSG1 Q9GZX9 SGTA Homo sapiens O43765
Validated Y2H
25416956
Intra
TWSG1 Q9GZX9 LRRC4C Homo sapiens Q9HCJ2
Y2H Prey Pooling
32296183
Intra
TWSG1 Q9GZX9 LRRC4C Homo sapiens Q9HCJ2
Validated Y2H
32296183
Intra
TWSG1 Q9GZX9 LRRC4C Homo sapiens Q9HCJ2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant TWSG1 Proteins

Cat. No. Product Name Accession Purity
HY-P71391 TWSG1 Protein, Human (HEK293, His) Q9GZX9-1 (C26-F223) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Breast Intraductal Papillomatosis

  • Breast Papillomatosis

  • Intraductal Papillomatosis Of The Breast
Holoprosencephaly

  • Holoprosencephaly Sequence

  • Hpe

  • Hpe - [Holoprosencephaly]
Cataract 37

  • CTRCT37

  • Cca5

  • Cataract, Congenital, Cerulean Type, 5

  • Cataract 37, Autosomal Dominant

  • Congenital Cataract Cerulean Type 5
Prolapse Of Urethra

  • Urethrocele
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15284 TWSG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17999 Twsg1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24471 Twsg1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TWSG1 VGNC VGNC:48004
Mus musculus TWSG1 MGD MGI:2137520
Felis catus TWSG1 VGNC VGNC:66718
Bos taurus TWSG1 VGNC VGNC:36528
Macaca mulatta TWSG1 VGNC VGNC:104255
Rattus norvegicus TWSG1 RGD RGD:1311215
Others TWSG1 NCBI