PTGFR - prostaglandin F receptor Gene

Also Known as FP

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5737

About PTGFR

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:78,490,974-78,540,701 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 7.8), urinary bladder (RPKM 5.1) and 16 other tissues.

Summary

The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTGFR Products (5)

mRNA Protein Name
NM_001039585.2 NP_001034674.1 prostaglandin F2-alpha receptor isoform b precursor
XM_047426101.1 XP_047282057.1 prostaglandin F2-alpha receptor isoform X3
XM_047426085.1 XP_047282041.1 prostaglandin F2-alpha receptor isoform X1
NM_000959.4 NP_000950.1 prostaglandin F2-alpha receptor isoform a precursor
XM_017001873.1 XP_016857362.1 prostaglandin F2-alpha receptor isoform X2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables prostaglandin F receptor activity IDA
IDA: Inferred from direct assay
18587449 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to prostaglandin D stimulus IMP
IMP: Inferred from mutant phenotype
18508192 GOA
involved in positive regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
18508192 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18508192 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
10575000 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
18508192 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGFR Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (58 - 304)

  • 0
  • 100
  • 200
  • 300
  • 359 a.a.
Protein Preferred Names Protein Names

prostaglandin F2-alpha receptor

  • FP prostanoid receptor

  • PGF receptor

  • PGF2 alpha receptor

  • prostaglandin receptor (2-alpha)

  • prostanoid FP receptor

Related Diseases

Diseases Alias
Ocular Hypertension

  • Hypertension, Ocular

  • Intraocular Pressure Increase

  • Oh - [Ocular Hypertension]

  • Oht - [Ocular Hypertension]
Intraocular Pressure Quantitative Trait Locus

  • Glaucoma

  • IOPQTL

  • Glaucoma, Susceptibility To

  • Postinfectious Glaucoma

  • Glaucoma With Ocular Inflammation

  • Glaucoma Secondary To Eye Inflammation

  • Traumatic Glaucoma

  • Glaucoma With Concussion Of Globe

  • Glaucoma Due To Ocular Trauma

  • Glaucoma Associated With Ocular Trauma

  • Glaucoma Secondary To Drugs
Open-Angle Glaucoma

  • Glaucoma Simplex

  • Pigmentary Glaucoma

  • Wide-Angle Glaucoma

  • Glaucoma, Open-Angle

  • Open Angle Glaucoma

  • Glaucoma Open-Angle

  • Chronic Simple Glaucoma

  • Coag - [Chronic Open-Angle Glaucoma]

  • Csg - [Chronic Simple Glaucoma]

  • Poag - [Primary Open-Angle Glaucoma]

  • Oag - [Open-Angle Glaucoma]

  • Chronic Glaucoma

  • Chronic Open Angle Glaucoma

  • Simple Glaucoma

  • Chronic Noncongestive Glaucoma

  • Ltg - [Low Tension Glaucoma]

  • Noncongestive Glaucoma

  • Nonobstructive Glaucoma

  • Normal Pressure Glaucoma

  • Primary Low Tension Glaucoma

  • Low-Tension Glaucoma

  • Residual Stage Low Tension Glaucoma

  • Open Cleft Glaucoma
Punctate Epithelial Keratoconjunctivitis

  • Punctate Keratitis

  • Thygeson Superficial Punctate Keratitis

  • Thygeson'S Superficial Punctate Keratitis

  • Thygeson Superficial Punctate Keratopathy

  • Punctate Epithelial Keratitis
Blepharoconjunctivitis
Glaucoma, Normal Tension

  • Low Tension Glaucoma

  • Glaucoma, Normal Tension, Susceptibility To

  • Normal Tension Glaucoma

  • Ntg

  • Glaucoma, Normal Pressure

  • NPG

  • Glaucoma, Normal Pressure, Susceptibility To

  • Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]
Enophthalmos
Ocular Hypotension

  • Hypotony Of Eye
Glaucoma, Primary Open Angle

  • Glaucoma 1, Open Angle, E

  • Primary Open Angle Glaucoma

  • POAG

  • Adult-Onset Primary Open Angle Glaucoma

  • Chronic Simple Glaucoma

  • GLC1E

  • Primary Open Angle Glaucoma 1e

  • Glaucoma, Open Angle, Primary
Ocular Hyperemia

  • Hyperemia Eye

  • Hyperemia Of Conjunctiva
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11382 PTGFR Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11383 Ptgfr Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS11384 Ptgfr Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PTGFR VGNC VGNC:69143
Macaca mulatta PTGFR VGNC VGNC:76584
Mus musculus PTGFR MGD MGI:97796
Bos taurus PTGFR VGNC VGNC:50251
Canis familiaris PTGFR VGNC VGNC:45147
Rattus norvegicus PTGFR RGD RGD:3436
Others PTGFR NCBI