PTGFR - prostaglandin F receptor Gene

Homo sapiens

Also known as FP

Gene ID: 5737 | Gene type: protein coding

About PTGFR

Cytogenetic location: 1p31.1 Genomic coordinates (GRCh38): 1:78,490,974-78,540,701 (from NCBI)

This gene has 4 transcripts (splice variants), 195 orthologues and 7 paralogues. Broad expression in endometrium (RPKM 7.8), urinary bladder (RPKM 5.1) and 16 other tissues.

Summary

The protein encoded by this gene is member of the G-protein coupled receptor family. This protein is a receptor for prostaglandin F2-alpha (PGF2-alpha), which is known to be a potent luteolytic agent, and may also be involved in modulating intraocular pressure and smooth muscle contraction in uterus. Knockout studies in mice suggest that the interaction of PGF2-alpha with this receptor may initiate parturition in ovarian luteal cells and thus induce luteolysis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PTGFR Products(5)

mRNA	Protein	Name
NM_001039585.2	NP_001034674.1	prostaglandin F2-alpha receptor isoform b precursor
XM_047426101.1	XP_047282057.1	prostaglandin F2-alpha receptor isoform X3
XM_047426085.1	XP_047282041.1	prostaglandin F2-alpha receptor isoform X1
NM_000959.4	NP_000950.1	prostaglandin F2-alpha receptor isoform a precursor
XM_017001873.1	XP_016857362.1	prostaglandin F2-alpha receptor isoform X2

PTGFR Protein Structure

7tm_1

0
100
200
300
359 a.a.

Protein Preferred Names

Protein Names

prostaglandin F2-alpha receptor

FP prostanoid receptor	PGF receptor
PGF2 alpha receptor	prostaglandin receptor (2-alpha)
prostanoid FP receptor

Related Diseases

Diseases

Alias

Ocular Hypertension

Hypertension, Ocular	Intraocular Pressure Increase
Oh - [Ocular Hypertension]	Oht - [Ocular Hypertension]

Intraocular Pressure Quantitative Trait Locus

Glaucoma	IOPQTL
Glaucoma, Susceptibility To	Postinfectious Glaucoma
Glaucoma With Ocular Inflammation	Glaucoma Secondary To Eye Inflammation
Traumatic Glaucoma	Glaucoma With Concussion Of Globe
Glaucoma Due To Ocular Trauma	Glaucoma Associated With Ocular Trauma
Glaucoma Secondary To Drugs

Open-Angle Glaucoma

Glaucoma Simplex	Pigmentary Glaucoma
Wide-Angle Glaucoma	Glaucoma, Open-Angle
Open Angle Glaucoma	Glaucoma Open-Angle
Chronic Simple Glaucoma	Coag - [Chronic Open-Angle Glaucoma]
Csg - [Chronic Simple Glaucoma]	Poag - [Primary Open-Angle Glaucoma]
Oag - [Open-Angle Glaucoma]	Chronic Glaucoma
Chronic Open Angle Glaucoma	Simple Glaucoma
Chronic Noncongestive Glaucoma	Ltg - [Low Tension Glaucoma]
Noncongestive Glaucoma	Nonobstructive Glaucoma
Normal Pressure Glaucoma	Primary Low Tension Glaucoma
Low-Tension Glaucoma	Residual Stage Low Tension Glaucoma
Open Cleft Glaucoma

Punctate Epithelial Keratoconjunctivitis

Punctate Keratitis	Thygeson Superficial Punctate Keratitis
Thygeson'S Superficial Punctate Keratitis	Thygeson Superficial Punctate Keratopathy
Punctate Epithelial Keratitis

Blepharoconjunctivitis

Glaucoma, Normal Tension

Low Tension Glaucoma	Glaucoma, Normal Tension, Susceptibility To
Normal Tension Glaucoma	Ntg
Glaucoma, Normal Pressure	NPG
Glaucoma, Normal Pressure, Susceptibility To	Poag/Npg - [Normal Pressure Primary Open-Angle Glaucoma]

Enophthalmos

Ocular Hypotension

Hypotony Of Eye

Glaucoma, Primary Open Angle

Glaucoma 1, Open Angle, E	Primary Open Angle Glaucoma
POAG	Adult-Onset Primary Open Angle Glaucoma
Chronic Simple Glaucoma	GLC1E
Primary Open Angle Glaucoma 1e	Glaucoma, Open Angle, Primary

Ocular Hyperemia

Hyperemia Eye

Hyperemia Of Conjunctiva

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS11382	PTGFR Human Pre-designed siRNA Set A	/	Unkown
HY-RS11383	Ptgfr Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS11384	Ptgfr Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	PTGFR	VGNC	VGNC:69143
Macaca mulatta	PTGFR	VGNC	VGNC:76584
Mus musculus	PTGFR	MGD	MGI:97796
Bos taurus	PTGFR	VGNC	VGNC:50251
Canis familiaris	PTGFR	VGNC	VGNC:45147
Rattus norvegicus	PTGFR	RGD	RGD:3436
Macaca fascicularis	PTGFR	NCBI	NCBI:102139926
Others	PTGFR	NCBI

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