NCOA5 - nuclear receptor coactivator 5 Gene

Also Known as CIA; bA465L10.6

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57727

About NCOA5

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:46,060,991-46,089,962 (from NCBI)

This gene has 2 transcripts (splice variants) and 202 orthologues. Ubiquitous expression in testis (RPKM 19.7), ovary (RPKM 15.7) and 25 other tissues.

Summary

This gene encodes a coregulator for the alpha and beta estrogen receptors and the Orphan Nuclear Receptor NR1D2. The protein localizes to the nucleus, and is thought to have both coactivator and corepressor functions. Its interaction with nuclear receptors is independent of the AF2 domain on the receptors, which is known to regulate interaction with Other coreceptors. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2017]

NCOA5 Products (5)

mRNA Protein Name
NM_001348148.2 NP_001335077.1 nuclear receptor coactivator 5 isoform 2
NM_001348149.2 NP_001335078.1 nuclear receptor coactivator 5 isoform 3
NM_001348150.2 NP_001335079.1 nuclear receptor coactivator 5 isoform 4
NM_001348151.2 NP_001335080.1 nuclear receptor coactivator 5 isoform 5
NM_020967.3 NP_066018.1 nuclear receptor coactivator 5 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11113208 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nuclear receptor coactivator 5

  • NCoA-5

Related Diseases

Diseases Alias
Night Blindness, Congenital Stationary, Type 1d

  • Congenital Stationary Night Blindness 1d

  • CSNB1D

  • Csnb, Complete, Autosomal Recessive

  • Night Blindness, Congenital Stationary , 1d, Autosomal Recessive

  • Congenital Stationary Night Blindness 1d Autosomal Recessive

  • Night Blindness, Congenital Stationary, 1d

  • Complete Autosomal Recessive Csnb

  • Blindness, Night, Stationary, Congenital, Type 1d
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09093 NCOA5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NCOA5 VGNC VGNC:31923
Macaca mulatta NCOA5 VGNC VGNC:74966
Felis catus NCOA5 VGNC VGNC:63741
Canis familiaris NCOA5 VGNC VGNC:43662
Rattus norvegicus NCOA5 RGD RGD:1307702
Mus musculus NCOA5 MGD MGI:2385165
Others NCOA5 NCBI