Bcl11b - B cell leukemia/lymphoma 11B Gene

Also Known as Rit1; Ctip2; BCL-11B; 9130430L19Rik; B630002E05Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 58208

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including animal organ development; cell morphogenesis involved in differentiation; and regulation of keratinocyte proliferation. Located in neuron projection and nucleus. Is expressed in several structures, including alimentary system; central nervous system; craniocervical region bone; nose; and skin. Human ortholog(s) of this gene implicated in immunodeficiency 49. Orthologous to human BCL11B (BAF chromatin remodeling complex subunit BCL11B). [provided by Alliance of Genome Resources, Apr 2022]

Bcl11b Products (3)

mRNA Protein Name
NM_001079883.1 NP_001073352.1 B-cell lymphoma/leukemia 11B isoform a
NM_001286343.1 NP_001273272.1 B-cell lymphoma/leukemia 11B isoform c
NM_021399.2 NP_067374.2 B-cell lymphoma/leukemia 11B isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
18595722 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16809611 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16809611 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
16809611 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
12717433 MGI
acts upstream of or within T cell differentiation in thymus IMP
IMP: Inferred from mutant phenotype
16670294 MGI
acts upstream of or within T cell receptor V(D)J recombination IMP
IMP: Inferred from mutant phenotype
12717433 MGI
acts upstream of or within alpha-beta T cell differentiation IMP
IMP: Inferred from mutant phenotype
12717433 MGI
acts upstream of apoptotic process IMP
IMP: Inferred from mutant phenotype
12717433 MGI
acts upstream of or within axonogenesis IMP
IMP: Inferred from mutant phenotype
15664173 MGI
acts upstream of or within central nervous system neuron differentiation IGI
IGI: Inferred from genetic interaction
18215621 MGI
acts upstream of or within commitment of neuronal cell to specific neuron type in forebrain IGI
IGI: Inferred from genetic interaction
23144223 MGI
acts upstream of or within epithelial cell morphogenesis IMP
IMP: Inferred from mutant phenotype
19251658 MGI
acts upstream of or within keratinocyte development IMP
IMP: Inferred from mutant phenotype
19092943 MGI
acts upstream of or within negative regulation of T cell apoptotic process IMP
IMP: Inferred from mutant phenotype
12717433 MGI
acts upstream of or within negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
12565905 MGI
acts upstream of or within negative regulation of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16670294 MGI
acts upstream of or within odontogenesis of dentin-containing tooth IMP
IMP: Inferred from mutant phenotype
19251658 MGI
acts upstream of or within olfactory bulb axon guidance IMP
IMP: Inferred from mutant phenotype
21752992 MGI
acts upstream of or within positive T cell selection IMP
IMP: Inferred from mutant phenotype
17998389 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16809611 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16809611 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12717433 MGI
acts upstream of or within post-embryonic camera-type eye development IMP
IMP: Inferred from mutant phenotype
12717433 MGI
acts upstream of or within post-embryonic development IMP
IMP: Inferred from mutant phenotype
12717433 MGI
acts upstream of or within regulation of gene expression IMP
IMP: Inferred from mutant phenotype
21752992 MGI
acts upstream of or within regulation of keratinocyte proliferation IMP
IMP: Inferred from mutant phenotype
19092943 MGI
acts upstream of or within regulation of lipid metabolic process IMP
IMP: Inferred from mutant phenotype
19092943 MGI
acts upstream of or within regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
21752992 MGI
acts upstream of or within skin development IMP
IMP: Inferred from mutant phenotype
19092943 MGI
acts upstream of or within striatal medium spiny neuron differentiation IMP
IMP: Inferred from mutant phenotype
18199763 MGI
acts upstream of thymocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
16670294 MGI
acts upstream of or within thymus development IMP
IMP: Inferred from mutant phenotype
12717433 MGI
acts upstream of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16809611 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: Inferred from genetic interaction
16809611 MGI
acts upstream of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
12717433 MGI
Cellular Component GO Annotation Evidence References Source
part of SWI/SNF complex IDA
IDA: Inferred from direct assay
23644491 MGI
located in intracellular anatomical structure IDA
IDA: Inferred from direct assay
18255031 MGI
located in neuron projection IDA
IDA: Inferred from direct assay
25100583 MGI
located in nucleus IDA
IDA: Inferred from direct assay
12565905 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

B-cell lymphoma/leukemia 11B

  • B-cell CLL/lymphoma 11B

  • B-cell lymphoma/leukaemia 11B

  • COUP-TF-interacting protein 2

  • mRit1

  • radiation-induced tumor suppressor gene 1 protein

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01414 BCL11B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21827 Bcl11b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28344 Bcl11b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Bcl11b NCBI NCBI:64919