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RABGGTA - Rab geranylgeranyltransferase subunit alpha Gene

Also Known as PTAR3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5875

About RABGGTA

Cytogenetic location: 14q12 Genomic coordinates (GRCh38): 14:24,265,538-24,271,627 (from NCBI)

This gene has 21 transcripts (splice variants), 1 gene allele, 181 orthologues and 2 paralogues. Ubiquitous expression in esophagus (RPKM 19.5), lung (RPKM 8.4) and 25 other tissues.

Summary

Predicted to enable small GTPase binding activity. Predicted to contribute to Rab geranylgeranyltransferase activity. Predicted to be involved in protein geranylgeranylation. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

RABGGTA Products (2)

mRNA	Protein	Name
NM_004581.5	NP_004572.3	geranylgeranyl transferase type-2 subunit alpha
NM_182836.3	NP_878256.1	geranylgeranyl transferase type-2 subunit alpha

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21905166	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RABGGTA Protein Structure

PPTA

RabGGT_insert

LRR_1

0
100
200
300
400
500
567 a.a.

Protein Preferred Names	Protein Names
geranylgeranyl transferase type-2 subunit alpha	Rab GG transferase alpha

RABGGTA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RABGGTA	Q92696	CHM	Homo sapiens	P24386	Anti Tag CoIP	21905166
Intra	RABGGTA	Q92696	CHM	Homo sapiens	P24386	Anti Tag CoIP	33961781
Intra	RABGGTA	Q92696	CHM	Homo sapiens	P24386	Anti Tag CoIP	28514442
Intra	RABGGTA	Q92696	CHM	Homo sapiens	P24386	Anti Tag CoIP	35271311
Intra	RABGGTA	Q92696	RABGGTB	Homo sapiens	P53611	Y2H Prey Pooling	32296183
Intra	RABGGTA	Q92696	RABGGTB	Homo sapiens	P53611	Anti Tag CoIP	35271311
Intra	RABGGTA	Q92696	RABGGTB	Homo sapiens	P53611	Anti Tag CoIP	33961781
Intra	RABGGTA	Q92696	RABGGTB	Homo sapiens	P53611	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Choroideremia	CHM Tcd Progressive Tapetochoroidal Dystrophy Choroidal Sclerosis Tapetochoroidal Dystrophy, Progressive Progressive Choroidal Atrophy Tapetochoroidal Dystrophy
Hermansky-Pudlak Syndrome	Hps Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells Hermanski-Pudlak Syndrome Hermansky Pudlak Syndrome Platelet Storage Pool Deficiency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11587	RABGGTA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RABGGTA	MGD	MGI:1860443
Rattus norvegicus	RABGGTA	RGD	RGD:621697
Macaca mulatta	RABGGTA	VGNC	VGNC:76640
Canis familiaris	RABGGTA	VGNC	VGNC:45303
Felis catus	RABGGTA	VGNC	VGNC:69207
Bos taurus	RABGGTA	VGNC	VGNC:33670
Others	RABGGTA	NCBI