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Mlxipl - MLX interacting protein-like Gene

Also Known as Mlx; ChREBP; WS-bHLH; Wbscr14; bHLHd14

Species: Mus musculus

Gene Type: protein coding

Gene ID: 58805

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Contributes to DNA binding activity. Involved in glucose mediated signaling pathway; positive regulation of fatty acid biosynthetic process; and regulation of nucleobase-containing compound metabolic process. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including central nervous system; gut; liver; metanephros; and nose. Used to study irritable bowel syndrome. Orthologous to human MLXIPL (MLX interacting protein like). [provided by Alliance of Genome Resources, Apr 2022]

Mlxipl Products (2)

mRNA	Protein	Name
NM_001359237.1	NP_001346166.1	carbohydrate-responsive element-binding protein isoform 2
NM_021455.5	NP_067430.2	carbohydrate-responsive element-binding protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
contributes to DNA binding	IDA IDA: Inferred from direct assay	11230181	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	21084751	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IGI IGI: Inferred from genetic interaction	21471514	MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: Inferred from mutant phenotype	15496471	MGI
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	18606808	MGI
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	11230181	MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11230181	MGI
enables RNA polymerase II-specific DNA-binding transcription factor binding	IDA IDA: Inferred from direct assay	11230181	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15163635	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in glucose homeostasis	IMP IMP: Inferred from mutant phenotype	15118080	MGI
involved in glucose mediated signaling pathway	IDA IDA: Inferred from direct assay	18591247	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11230181	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11230181	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	15163635	MGI
involved in positive regulation of fatty acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	15118080	MGI
involved in positive regulation of glycolytic process	IDA IDA: Inferred from direct assay	14742444	MGI
involved in positive regulation of glycolytic process	IMP IMP: Inferred from mutant phenotype	15118080	MGI
involved in positive regulation of lipid biosynthetic process	IGI IGI: Inferred from genetic interaction	21471514	MGI
involved in positive regulation of lipid biosynthetic process	IMP IMP: Inferred from mutant phenotype	15496471	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	18606808	MGI
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	15118080	MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose	IDA IDA: Inferred from direct assay	14742444	MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose	IGI IGI: Inferred from genetic interaction	21471514	MGI
involved in positive regulation of transcription from RNA polymerase II promoter by glucose	IMP IMP: Inferred from mutant phenotype	15496471	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	15163635	MGI
is active in nucleoplasm	IDA IDA: Inferred from direct assay	18606808	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	21084751	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15163635	MGI
is active in nucleus	IMP IMP: Inferred from mutant phenotype	15496471	MGI
part of transcription regulator complex	IDA IDA: Inferred from direct assay	11230181	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
carbohydrate-responsive element-binding protein	MLX interacting protein-like beta MLX interactor Max-like protein Williams-Beuren syndrome chromosome region 14 homolog putative hepatic transcription factor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08505	MLXIPL Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21156	Mlxipl Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27672	Mlxipl Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mlxipl	NCBI	NCBI:51085