Pias4 - protein inhibitor of activated STAT 4 Gene

Also Known as PIASY; Piasg; Pias-gamma

Species: Mus musculus

Gene Type: protein coding

Gene ID: 59004

Summary

Enables several functions, including SUMO Ligase activity; transcription corepressor activity; and ubiquitin protein Ligase binding activity. Involved in negative regulation of NF-kappaB transcription factor activity; negative regulation of transcription by RNA polymerase II; and positive regulation of keratinocyte apoptotic process. Acts upstream of or within negative regulation of tumor necrosis factor-mediated signaling pathway; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and protein sumoylation. Located in nuclear matrix and nucleoplasm. Part of transferase complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; hair follicle; and heart. Orthologous to human PIAS4 (protein inhibitor of activated STAT 4). [provided by Alliance of Genome Resources, Apr 2022]

Pias4 Products (1)

mRNA	Protein	Name
NM_021501.4	NP_067476.2	E3 SUMO-protein ligase PIAS4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	11731474	MGI
enables SUMO ligase activity	IDA IDA: Inferred from direct assay	19955185	MGI
enables SUMO transferase activity	IDA IDA: Inferred from direct assay	11731474	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	11731474	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	11731474	MGI
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	16816390	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within central nervous system development	IEP IEP: Inferred from expression pattern	10854042	MGI
acts upstream of or within hair follicle development	IEP IEP: Inferred from expression pattern	10854042	MGI
acts upstream of or within limb epidermis development	IEP IEP: Inferred from expression pattern	10854042	MGI
involved in negative regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	16816390	MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11731474	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	19955185	MGI
acts upstream of or within negative regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	20054338	MGI
acts upstream of or within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage	IDA IDA: Inferred from direct assay	16816390	MGI
involved in positive regulation of keratinocyte apoptotic process	IDA IDA: Inferred from direct assay	16816390	MGI
acts upstream of or within protein sumoylation	IDA IDA: Inferred from direct assay	11731474	MGI
involved in protein sumoylation	IDA IDA: Inferred from direct assay	19955185	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear matrix	IDA IDA: Inferred from direct assay	11731474	MGI
located in nucleoplasm	IDA IDA: Inferred from direct assay	16162816	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11731474	MGI
part of transferase complex	IDA IDA: Inferred from direct assay	19955185	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
E3 SUMO-protein ligase PIAS4	RING-type E3 ubiquitin transferase PIAS4 protein inhibitor of activated STAT PIASy protein inhibitor of activated STAT protein 4 protein inhibitor of activated STAT protein gamma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114366	BC-1485	Inhibitor	/	Unkown
HY-RS10476	PIAS4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21021	Pias4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27538	Pias4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pias4	NCBI	NCBI:51588