Myoz2 - myozenin 2 Gene

Also Known as Fatz-2; Myozl2; 1110012I24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 59006

Summary

Enables actin binding activity. Involved in several processes, including negative regulation of calcineurin-NFAT signaling cascade; sarcomere organization; and skeletal muscle fiber adaptation. Located in Z disc and actin Cytoskeleton. Is expressed in several structures, including diaphragm; foregut; heart; liver; and skeletal musculature. Human ortholog(s) of this gene implicated in hypertrophic cardiomyopathy 16. Orthologous to human MYOZ2 (myozenin 2). [provided by Alliance of Genome Resources, Apr 2022]

Myoz2 Products (2)

mRNA Protein Name
NM_001355462.1 NP_001342391.1 myozenin-2 isoform 2
NM_021503.2 NP_067478.1 myozenin-2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IPI
IPI: Inferred from physical interaction
11114196 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of calcineurin-NFAT signaling cascade IDA
IDA: Inferred from direct assay
15543153 MGI
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
15543153 MGI
involved in sarcomere organization IDA
IDA: Inferred from direct assay
15543153 MGI
involved in skeletal muscle fiber adaptation IDA
IDA: Inferred from direct assay
15543153 MGI
involved in skeletal muscle tissue development IDA
IDA: Inferred from direct assay
15543153 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
15543153 MGI
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
11114196 MGI
located in actin cytoskeleton IPI
IPI: Inferred from physical interaction
11114196 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

myozenin-2

  • FATZ-related protein 2

  • calsarcin-1

  • myozenin-like 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08966 MYOZ2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22666 Myoz2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29180 Myoz2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Myoz2 NCBI NCBI:51778