CARD18 - caspase recruitment domain family member 18 Gene

Also Known as ICEBERG; UNQ5804; pseudo-ICE

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 59082

About CARD18

Cytogenetic location: 11q22.3 Genomic coordinates (GRCh38): 11:105,137,714-105,139,769 (from NCBI)

This gene has 5 transcripts (splice variants), 451 orthologues and 16 paralogues. Biased expression in skin (RPKM 6.9) and esophagus (RPKM 0.8).

Summary

Enables CARD domain binding activity and Caspase binding activity. Involved in inhibition of cysteine-type endopeptidase activity; negative regulation of interleukin-1 beta production; and negative regulation of protein binding activity. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

CARD18 Products (1)

mRNA Protein Name
NM_021571.4 NP_067546.1 caspase recruitment domain-containing protein 18

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables CARD domain binding IPI
IPI: Inferred from physical interaction
11821383 GOA
enables caspase binding IPI
IPI: Inferred from physical interaction
11536016 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11536016 GOA
Biological Process GO Annotation Evidence References Source
involved in inhibition of cysteine-type endopeptidase activity IDA
IDA: Inferred from direct assay
11821383 GOA
involved in negative regulation of interleukin-1 beta production IDA
IDA: Inferred from direct assay
11536016 GOA
involved in negative regulation of protein binding IDA
IDA: Inferred from direct assay
11536016 GOA
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
11536016 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CARD18 Protein Structure

CARD

CARD: Caspase recruitment domain (4 - 89)

  • 0
  • 90 a.a.
Protein Preferred Names Protein Names

caspase recruitment domain-containing protein 18

  • ICEBERG caspase-1 inhibitor

Related Diseases

Diseases Alias
Asbestos-Related Lung Carcinoma
Colon Sarcoma

  • Colonic Sarcoma
Alveolar Periostitis

  • Dry Socket

  • Alveolitis Of Jaw

  • Dry Tooth Socket

  • Alveolar Pyorrhea

  • Alveolar Osteitis

  • Alveolitis Sicca Dolorosa

  • Alveolodental Periostitis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01919 CARD18 Human Pre-designed siRNA Set A Pre-designed Set / Unkown