Twist2 - twist family bHLH transcription factor 2 Gene

Also Known as Dermo1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 59327

Summary

Predicted to enable several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in negative regulation of apoptotic process. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Predicted to be part of transcription regulator complex. Human ortholog(s) of this gene implicated in Barber-Say syndrome; ablepharon macrostomia syndrome; and focal dermal hypoplasia. Orthologous to human TWIST2 (twist family bHLH transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Twist2 Products (1)

mRNA Protein Name
NM_021691.2 NP_067723.1 twist-related protein 2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
10485844 RGD
involved in response to insulin IEP
IEP: Inferred from expression pattern
20818503 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
20818503 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

twist-related protein 2

  • dermo-1 protein

  • twist basic helix-loop-helix transcription factor 2

  • twist homolog 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15282 TWIST2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21968 Twist2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28485 Twist2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Twist2 NCBI NCBI:117581