HRH4 - histamine receptor H4 Gene

Also Known as H4; H4R; BG26; HH4R; AXOR35; GPRv53; GPCR105

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 59340

About HRH4

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:24,460,637-24,479,974 (from NCBI)

This gene has 2 transcripts (splice variants), 105 orthologues and 25 paralogues. Low expression observed in reference dataset.

Summary

Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by a family of histamine receptors, which are a subset of the G-protein coupled receptor superfamily. This gene encodes a Histamine Receptor that is predominantly expressed in haematopoietic cells. The protein is thought to play a role in inflammation and allergy reponses. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]

HRH4 Products (3)

mRNA Protein Name
NM_021624.4 NP_067637.2 histamine H4 receptor isoform 1
NM_001160166.2 NP_001153638.1 histamine H4 receptor isoform 3
NM_001143828.2 NP_001137300.1 histamine H4 receptor isoform 2

HRH4 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (32 - 358)

  • 0
  • 100
  • 200
  • 300
  • 390 a.a.
Protein Preferred Names Protein Names

histamine H4 receptor

  • G-protein coupled receptor 105

  • SP9144

  • pfi-013

Related Diseases

Diseases Alias
Chronic Conjunctivitis
Meniere Disease

  • Meniere'S Disease

  • Otogenic Vertigo

  • Ménière Disease

  • Ménière'S Disease

  • Mnire'S Vertigo

  • Auditory Vertigo

  • Aural Vertigo

  • Meniere'S Syndrome

  • Ménière'S Vertigo

  • Primary Endolymphatic Hydrops

  • Menieres Disease

  • Vertigo, Aural

  • Labyrinth Hydrops

  • Labyrinthine Hydrops

  • Labyrinthine Vertigo

  • Ménière Syndrome

  • Ménière Vertigo

  • Idiopathic Endolymphatic Hydrops
Paraneoplastic Cerebellar Degeneration

  • Pcd

  • Paraneoplastic Cerebellar Ataxia

  • Rapidely Progressive Cerebellar Syndrome

  • Subacute Cerebellar Degeneration
Dermatitis, Atopic

  • Atopic Dermatitis

  • Atopic Eczema

  • Dermatitis, Atopic, Susceptibility To, 1

  • Atod

  • Eczema, Atopic

  • Dermatitis, Atopic 1

  • Allergic Dermatitis

  • Atopic Neurodermatitis

  • Besnier'S Prurigo

  • Dermatitis, Atopic, 1

  • Dermatitis Atopic

  • Eczema

  • Besnier Prurigo
Pericarditis
Allergic Conjunctivitis

  • Conjunctivitis Allergic

  • Conjunctivitis, Allergic

  • Allergen-Induced Conjunctivitis

  • Seasonal Allergic Conjunctivitis

  • Perennial Allergic Conjunctivitis

  • Spring Conjunctivitis

  • Acute Allergic Conjunctivitis
Allergic Disease

  • Hypersensitivity

  • Allergic Hypersensitivity Disease

  • Allergic Condition

  • Allergic Reaction

  • Allergic Disposition
Nasal Cavity Disease

  • Disorder Of Nasal Cavity
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06368 HRH4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06369 Hrh4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS06370 Hrh4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris HRH4 VGNC VGNC:41788
Macaca mulatta HRH4 VGNC VGNC:73404
Felis catus HRH4 VGNC VGNC:62841
Bos taurus HRH4 VGNC VGNC:29956
Mus musculus HRH4 MGD MGI:2429635
Rattus norvegicus HRH4 RGD RGD:620631
Others HRH4 NCBI