RPS7 - ribosomal protein S7 Gene

Also Known as S7; eS7; DBA8

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6201

About RPS7

Cytogenetic location: 2p25.3 Genomic coordinates (GRCh38): 2:3,575,260-3,580,920 (from NCBI)

This gene has 12 transcripts (splice variants), 228 orthologues and is associated with 2 phenotypes. Ubiquitous expression in ovary (RPKM 822.9), bone marrow (RPKM 559.6) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPS7 Products (1)

mRNA Protein Name
NM_001011.4 NP_001002.1 40S ribosomal protein S7

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables mRNA 3'-UTR binding IDA
IDA: Inferred from direct assay
16213212 GOA
enables mRNA 5'-UTR binding IDA
IDA: Inferred from direct assay
16213212 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9687515 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
20873783 GOA
enables structural constituent of ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
enables structural constituent of ribosome IMP
IMP: Inferred from mutant phenotype
18697920 GOA
enables ubiquitin ligase inhibitor activity IDA
IDA: Inferred from direct assay
17310983 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
17310983 GOA
involved in negative regulation of ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
17310983 GOA
involved in positive regulation of gene expression IMP
IMP: Inferred from mutant phenotype
17310983 GOA
involved in positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: Inferred from mutant phenotype
17310983 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
17310983 GOA
involved in rRNA processing IMP
IMP: Inferred from mutant phenotype
18697920 GOA
involved in ribosomal small subunit biogenesis IDA
IDA: Inferred from direct assay
34516797 GOA
involved in ribosomal small subunit biogenesis IMP
IMP: Inferred from mutant phenotype
18697920 GOA
Cellular Component GO Annotation Evidence References Source
colocalizes with centrosome IDA
IDA: Inferred from direct assay
20873783 GOA
located in cytosolic ribosome IDA
IDA: Inferred from direct assay
23636399 GOA
part of cytosolic small ribosomal subunit IDA
IDA: Inferred from direct assay
8706699 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
11823430 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9687515 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20873783 GOA
part of protein-containing complex IMP
IMP: Inferred from mutant phenotype
17310983 GOA
part of ribonucleoprotein complex IDA
IDA: Inferred from direct assay
18809582 GOA
part of small-subunit processome IDA
IDA: Inferred from direct assay
34516797 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPS7 Protein Structure

Ribosomal_S7e

Ribosomal_S7e: Ribosomal protein S7e (7 - 191)

  • 0
  • 100
  • 194 a.a.
Protein Preferred Names Protein Names

40S ribosomal protein S7

  • small ribosomal subunit protein eS7

RPS7 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RPS7 P62081 MDM2 Homo sapiens Q00987
Anti Tag CoIP
33961781
Intra
RPS7 P62081 MDM2 Homo sapiens Q00987
Anti Tag CoIP
17310983
Intra
RPS7 P62081 NEDD8 Homo sapiens Q15843
Pull Down
18274552
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RPS7 Proteins

Cat. No. Product Name Accession Purity
HY-P71266 RPS7 Protein, Human (His) P62081 (M1-L194) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Diamond-Blackfan Anemia 8

  • DBA8

  • Rps7-Related Diamond-Blackfan Anemia

  • Anemia, Diamond-Blackfan, Type 8
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Macrocytic Anemia

  • Anemia Macrocytic

  • Anemia, Macrocytic

  • Macrocytic Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12269 RPS7 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19638 Rps7 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26132 Rps7 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RPS7 MGD MGI:1333818
Canis familiaris RPS7 VGNC VGNC:45748
Bos taurus RPS7 VGNC VGNC:34150
Macaca mulatta RPS7 VGNC VGNC:106214
Rattus norvegicus RPS7 RGD RGD:61907
Others RPS7 NCBI