RTN1 - reticulon 1 Gene

Also Known as NSP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6252

About RTN1

Cytogenetic location: 14q23.1 Genomic coordinates (GRCh38): 14:59,595,976-59,870,776 (from NCBI)

This gene has 8 transcripts (splice variants), 228 orthologues and 4 paralogues. Biased expression in brain (RPKM 96.0) and spleen (RPKM 6.9).

Summary

This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. This gene is considered to be a specific marker for neurological diseases and Cancer, and is a potential molecular target for therapy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2011]

RTN1 Products (3)

mRNA	Protein	Name
NM_001363702.1	NP_001350631.1	reticulon-1 isoform D
NM_021136.3	NP_066959.1	reticulon-1 isoform A
NM_206852.3	NP_996734.1	reticulon-1 isoform C

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12873973	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of amyloid-beta formation	IDA IDA: Inferred from direct assay	15286784	GOA
involved in neuron differentiation	IEP IEP: Inferred from expression pattern	9560466	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	12873973	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	12873973	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	17684057	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RTN1 Protein Structure

Reticulon

0
200
400
600
776 a.a.

Protein Preferred Names	Protein Names
reticulon-1	neuroendocrine-specific protein

RTN1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89622	Rtn-1A/B Antibody (YA8966)	WB, ICC/IF, IF-Tissue, FC, IP	human

Related Diseases

Diseases	Alias
Hereditary Spastic Paraplegia	Familial Spastic Paraplegia Hereditary Spastic Paraparesis Strumpell-Lorrain Disease Familial Spastic Paraparesis Hsp Spg Strümpell-Lorrain Disease Spastic Paraplegia, Hereditary French Settlement Disease Strumpell-Lorrain Syndrome Fsp Spastic Paraplegia, Familial Spastic Paraplegia Hereditary Spastic Paraplegia 3, Autosomal Dominant Spastic Paraparesis Hereditary Spastic Paralysis Familial Spastic Paralysis Hereditary Spastic Ataxia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12329	RTN1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	RTN1	VGNC	VGNC:64810
Canis familiaris	RTN1	VGNC	VGNC:51680
Mus musculus	RTN1	MGD	MGI:1933947
Bos taurus	RTN1	VGNC	VGNC:34203
Rattus norvegicus	RTN1	RGD	RGD:620986
Macaca mulatta	RTN1	VGNC	VGNC:84762
Others	RTN1	NCBI