Sav1 - salvador family WW domain containing 1 Gene

Also Known as Sav; Salv; WW45; Wwp3; Wwp4; 1700040G09Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 64010

Summary

Predicted to enable several functions, including identical protein binding activity; signaling receptor binding activity; and signaling receptor complex adaptor activity. Acts upstream of or within several processes, including epithelial cell differentiation; hippo signaling; and negative regulation of cell population proliferation. Predicted to be located in cytosol and nucleus. Predicted to be active in cell-cell junction; cytoplasm; and dendrite. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Used to study colonic disease and hepatocellular carcinoma. Orthologous to human SAV1 (salvador family WW domain containing protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Sav1 Products (1)

mRNA Protein Name
NM_022028.2 NP_071311.1 protein salvador homolog 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
22292086 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
21512031 MGI
acts upstream of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within hair follicle development IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within hippo signaling IGI
IGI: Inferred from genetic interaction
18369314 MGI
acts upstream of or within hippo signaling IMP
IMP: Inferred from mutant phenotype
21512031 MGI
involved in hippo signaling IMP
IMP: Inferred from mutant phenotype
20080689 MGI
acts upstream of or within intestinal epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of keratinocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within keratinocyte differentiation IGI
IGI: Inferred from genetic interaction
18369314 MGI
acts upstream of or within keratinocyte differentiation IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within lung epithelial cell differentiation IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within negative regulation of cardiac muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
21512031 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within positive regulation of fat cell differentiation IGI
IGI: Inferred from genetic interaction
22292086 MGI
acts upstream of or within positive regulation of keratinocyte apoptotic process IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within regulation of organ growth IMP
IMP: Inferred from mutant phenotype
21512031 MGI
acts upstream of or within regulation of stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
18369314 MGI
acts upstream of or within ventricular septum morphogenesis IMP
IMP: Inferred from mutant phenotype
21512031 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein salvador homolog 1

  • 45 kDa WW domain protein

  • WW domain-containing protein 3

  • WW domain-containing protein 4

  • salvador homolog 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12460 SAV1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18789 Sav1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25278 Sav1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sav1 NCBI NCBI:60485