ACOT1 - acyl-CoA thioesterase 1 Gene

Also Known as ACH2; CTE-1; LACH2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 641371

About ACOT1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,490,933-73,543,796 (from NCBI)

This gene has 2 transcripts (splice variants), 436 orthologues and 4 paralogues. Broad expression in fat (RPKM 27.2), liver (RPKM 24.9) and 24 other tissues.

Summary

Enables acyl-CoA hydrolase activity. Involved in acyl-CoA metabolic process; long-chain fatty acid metabolic process; and very long-chain fatty acid metabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

ACOT1 Products (1)

mRNA Protein Name
NM_001037161.2 NP_001032238.1 acyl-coenzyme A thioesterase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables fatty acyl-CoA hydrolase activity IDA
IDA: Inferred from direct assay
16940157 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
Biological Process GO Annotation Evidence References Source
involved in acyl-CoA metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
involved in very long-chain fatty acid metabolic process IDA
IDA: Inferred from direct assay
16940157 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
16940157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ACOT1 Protein Structure

Bile_Hydr_Trans

Bile_Hydr_Trans: Acyl-CoA thioester hydrolase/BAAT N-terminal region (15 - 141)

BAAT_C

BAAT_C: BAAT / Acyl-CoA thioester hydrolase C terminal (204 - 411)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 421 a.a.
Protein Preferred Names Protein Names

acyl-coenzyme A thioesterase 1

  • CTE-I

Related Diseases

Diseases Alias
Aztreonam Allergy

  • Azactam Allergy

  • Primbactam Allergy
Cefaclor Allergy

  • Ceclor Allergy

  • Cephaclor Allergy
Cefuroxime Allergy

  • Cephuroxime Allergy

  • Zinacef Allergy
Ceftriaxone Allergy

  • Rocephin Allergy
Anorectal Stricture

  • Stenosis Of Rectum And Anus

  • Anorectal Malformations
Mitochondrial Pyruvate Carrier Deficiency

  • MPYCD
Pitt-Hopkins-Like Syndrome 2

  • PTHSL2

  • Mesh

  • D006985

  • Mesh

  • D008607
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00173 ACOT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21470 Acot1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27988 Acot1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ACOT1 RGD RGD:70894
Mus musculus ACOT1 MGD MGI:1349396