SH3BGRL - SH3 domain binding glutamate rich protein like Gene

Also Known as SH3BGR; HEL-S-115

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6451

About SH3BGRL

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:81,202,102-81,298,547 (from NCBI)

This gene has 4 transcripts (splice variants), 227 orthologues and 3 paralogues. Ubiquitous expression in endometrium (RPKM 90.2), urinary bladder (RPKM 79.0) and 25 other tissues.

Summary

Predicted to enable SH3 domain binding activity. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

SH3BGRL Products (1)

mRNA Protein Name
NM_003022.3 NP_003013.1 adapter SH3BGRL

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein-RNA adaptor activity IMP
IMP: Inferred from mutant phenotype
34331014 GOA
enables ubiquitin-like ligase-substrate adaptor activity IMP
IMP: Inferred from mutant phenotype
34331014 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cytoplasmic translational initiation IMP
IMP: Inferred from mutant phenotype
34331014 GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: Inferred from mutant phenotype
34331014 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
34870550 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SH3BGRL Protein Structure

SH3BGR

SH3BGR: SH3-binding, glutamic acid-rich protein (1 - 98)

  • 0
  • 100
  • 114 a.a.
Protein Preferred Names Protein Names

adapter SH3BGRL

SH3 domain-binding glutamic acid-rich-like protein

  • SH3 domain binding glutamic acid-rich protein like

Related Diseases

Diseases Alias
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12827 SH3BGRL Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12828 SH3BGRL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12829 SH3BGRL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SH3BGRL VGNC VGNC:65099
Macaca mulatta SH3BGRL VGNC VGNC:77200
Mus musculus SH3BGRL MGD MGI:1930849
Rattus norvegicus SH3BGRL RGD RGD:1560520
Canis familiaris SH3BGRL VGNC VGNC:46116
Bos taurus SH3BGRL VGNC VGNC:34564
Others SH3BGRL NCBI