ENTPD1 - Entpd1 ectonucleoside triphosphate diphosphohydrolase 1 Gene

Also Known as NTPDase-1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 64519

Summary

Enables ATP hydrolysis activity; adenosine-diphosphatase activity; and identical protein binding activity. Involved in several processes, including cellular response to cytokine stimulus; response to amino acid; and response to purine-containing compound. Located in several cellular components, including basolateral plasma membrane; postsynaptic density; and synaptic vesicle. Biomarker of demyelinating disease; hypothyroidism; intrahepatic cholestasis; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 64. Orthologous to human ENTPD1 (ectonucleoside triphosphate diphosphohydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

ENTPD1 Products (1)

mRNA	Protein	Name
NM_022587.2	NP_072109.2	ectonucleoside triphosphate diphosphohydrolase 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ADP phosphatase activity	IDA IDA: Inferred from direct assay	18841405	RGD
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	18841405	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	12694193	RGD
enables nucleoside diphosphate phosphatase activity	IDA IDA: Inferred from direct assay	9221928	RGD
enables ribonucleoside triphosphate phosphatase activity	IDA IDA: Inferred from direct assay	9221928	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to aluminum ion	IEP IEP: Inferred from expression pattern	20832780	RGD
involved in cellular response to interferon-alpha	IEP IEP: Inferred from expression pattern	23990338	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	23990338	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	23990338	RGD
involved in negative regulation of ATP biosynthetic process	IMP IMP: Inferred from mutant phenotype	21325440	RGD
involved in negative regulation of dopamine secretion	IMP IMP: Inferred from mutant phenotype	21325440	RGD
involved in response to ATP	IEP IEP: Inferred from expression pattern	20223894	RGD
involved in response to L-arginine	IEP IEP: Inferred from expression pattern	12615083	RGD
involved in response to auditory stimulus	IEP IEP: Inferred from expression pattern	15183524	RGD
involved in response to caffeine	IEP IEP: Inferred from expression pattern	12834266	RGD
involved in response to gamma radiation	IEP IEP: Inferred from expression pattern	19169047	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	11383876	RGD
involved in response to proline	IEP IEP: Inferred from expression pattern	17407768	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	11383876	RGD
located in cell surface	IDA IDA: Inferred from direct assay	15673609	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	18997343	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15183524	RGD
located in synaptic membrane	IDA IDA: Inferred from direct assay	15730886	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	9593967	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
ectonucleoside triphosphate diphosphohydrolase 1	ATPDase NTPDase 1 ecto-ATP diphosphohydrolase 1 ecto-ATPDase 1 ecto-ATPase 1 ecto-apyrase lymphoid cell activation antigen

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990068	Perenostobart	Inhibitor	97.00%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04395	ENTPD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18563	Entpd1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25045	Entpd1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P992099	Afivastobart	Inhibitor	99.36%	Unkown
HY-P991701	Mebarase alfa	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	ENTPD1	NCBI	NCBI:953