Rab5a - RAB5A, member RAS oncogene family Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 64633

Summary

Enables GDP-dissociation inhibitor binding activity. Involved in several processes, including positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including cytoplasmic vesicle; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is anchored component of synaptic vesicle membrane. Orthologous to human RAB5A (RAB5A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab5a Products (1)

mRNA Protein Name
NM_022692.2 NP_073183.1 ras-related protein Rab-5A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GDP-dissociation inhibitor binding IDA
IDA: Inferred from direct assay
14709549 RGD
Biological Process GO Annotation Evidence References Source
involved in endocytosis IMP
IMP: Inferred from mutant phenotype
16154939 RGD
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
8043272 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
21125971 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: Inferred from mutant phenotype
21125971 RGD
involved in postsynaptic neurotransmitter receptor internalization IDA
IDA: Inferred from direct assay
15629704 RGD
involved in postsynaptic neurotransmitter receptor internalization IMP
IMP: Inferred from mutant phenotype
15629704 RGD
involved in regulation of long-term neuronal synaptic plasticity IMP
IMP: Inferred from mutant phenotype
18653660 RGD
involved in synaptic vesicle endocytosis IDA
IDA: Inferred from direct assay
20956291 RGD
involved in synaptic vesicle endocytosis IMP
IMP: Inferred from mutant phenotype
20956291 RGD
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
8043272 RGD
located in axon terminus IDA
IDA: Inferred from direct assay
8043272 RGD
located in dendrite IDA
IDA: Inferred from direct assay
8043272 RGD
located in early endosome IDA
IDA: Inferred from direct assay
18353411 RGD
located in endosome IDA
IDA: Inferred from direct assay
8043272 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
15629704 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
15629704 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
8043272 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
12703553 RGD
is active in postsynaptic endocytic zone membrane IDA
IDA: Inferred from direct assay
15629704 RGD
is active in postsynaptic endocytic zone membrane IMP
IMP: Inferred from mutant phenotype
15629704 RGD
is active in presynaptic endosome IDA
IDA: Inferred from direct assay
31074746 RGD
is active in presynaptic endosome IMP
IMP: Inferred from mutant phenotype
31074746 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
14709549 RGD
located in recycling endosome IDA
IDA: Inferred from direct assay
10468577 RGD
located in somatodendritic compartment IDA
IDA: Inferred from direct assay
8043272 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
8043272 RGD
is active in synaptic vesicle membrane EXP
EXP: Inferred from Experiment
20926670 RGD
is active in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
20926670 RGD
located in synaptic vesicle membrane IDA
IDA: Inferred from direct assay
20926670 RGD
is active in synaptic vesicle membrane IMP
IMP: Inferred from mutant phenotype
20926670 RGD
located in zymogen granule membrane IDA
IDA: Inferred from direct assay
8166729 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related protein Rab-5A

  • small GTP-binding protein rab5

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11571 RAB5A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21715 Rab5a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28233 Rab5a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rab5a NCBI NCBI:5868