ANAPC1 - anaphase promoting complex subunit 1 Gene

Also Known as APC1; MCPR; TSG24

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64682

About ANAPC1

Cytogenetic location: 2q13 Genomic coordinates (GRCh38): 2:111,766,231-111,884,193 (from NCBI)

This gene has 11 transcripts (splice variants), 213 orthologues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 7.2), lymph node (RPKM 6.5) and 25 other tissues.

Summary

This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin Ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011]

ANAPC1 Products (1)

mRNA Protein Name
NM_022662.4 NP_073153.1 anaphase-promoting complex subunit 1

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein K11-linked ubiquitination IDA
IDA: Inferred from direct assay
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: Inferred from direct assay
29033132 GOA
Cellular Component GO Annotation Evidence References Source
part of anaphase-promoting complex IDA
IDA: Inferred from direct assay
16364912 GOA
part of anaphase-promoting complex IPI
IPI: Inferred from physical interaction
27120157 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANAPC1 Protein Structure

ANAPC1

ANAPC1: Anaphase-promoting complex subunit 1 (149 - 227)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1944 a.a.
Protein Preferred Names Protein Names

anaphase-promoting complex subunit 1

  • anaphase-promoting complex 1 (meiotic checkpoint regulator)

ANAPC1 Antibodies

Cat. No. Product Name Application Reactivity
HY-P84789 ANAPC1 Antibody (YA4486) ICC/IF, FC, ELISA Human
HY-P84789A ANAPC1 Antibody (YA4486)(PBS only) ICC/IF, FC, ELISA Human

Related Diseases

Diseases Alias
Rothmund-Thomson Syndrome, Type 1

  • RTS1

  • Poikiloderma Atrophicans And Cataract

  • Rothmund-Thomson Syndrome Type 1

  • Poikiloderma Of Rothmund-Thomson Type 1

  • Rothmund-Thomson Syndrome 1
Rothmund-Thomson Syndrome, Type 2

  • Rothmund-Thomson Syndrome

  • Rts

  • RTS2

  • Poikiloderma Of Rothmund-Thomson

  • Rothmund-Thomson Syndrome Type 2

  • Congenital Poikiloderma

  • Poikiloderma Congenitale

  • Poikiloderma Atrophicans And Cataract

  • Poikiloderma Congenitale Of Rothmund-Thomson

  • Poikiloderma Of Rothmund-Thomson Type 2

  • Rothmund-Thomson Syndrome 2

  • Erythrokeratodermia Variabilis
Fuchs' Endothelial Dystrophy

  • Fuchs Endothelial Corneal Dystrophy

  • Fuchs Endothelial Dystrophy

  • Fuchs Dystrophy

  • Fced

  • Fuchs' Corneal Dystrophy

  • Fuchs' Endothelial Corneal Dystrophy

  • Fuchs Atrophy

  • Fuchs Corneal Dystrophy

  • Endoepithelial Corneal Dystrophy

  • Fecd

  • Late Hereditary Endothelial Dystrophy

  • Corneal Dystrophy, Fuchs Endothelial

  • Dystrophy, Corneal, Fuchs Endothelial

  • Corneal Dystrophy, Fuchs' Endothelial, 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00677 ANAPC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21090 Anapc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27608 Anapc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ANAPC1 MGD MGI:103097
Bos taurus ANAPC1 VGNC VGNC:25879
Canis familiaris ANAPC1 VGNC VGNC:37844
Rattus norvegicus ANAPC1 RGD RGD:1306629
Felis catus ANAPC1 VGNC VGNC:59774
Macaca mulatta ANAPC1 VGNC VGNC:69640
Others ANAPC1 NCBI