IPPK - inositol-pentakisphosphate 2-kinase Gene

Also Known as IP5K; IPK1; C9orf12; INSP5K2; bA476B13.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64768

About IPPK

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:92,613,183-92,670,131 (from NCBI)

This gene has 3 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in skin (RPKM 15.1), esophagus (RPKM 8.3) and 24 other tissues.

Summary

The protein encoded by this gene is a kinase that phosphorylates position 2 of inositol-1,3,4,5,6-pentakisphosphate to form inositol-1,2,3,4,5,6-hexakisphosphate (InsP6). InsP6 has a variety of functions, including stimulation of DNA repair, endocytosis, and mRNA export. [provided by RefSeq, Nov 2010]

IPPK Products (1)

mRNA	Protein	Name
NM_022755.6	NP_073592.1	inositol-pentakisphosphate 2-kinase

IPPK Protein Structure

Ins_P5_2-kin

0
100
200
300
400
491 a.a.

Protein Preferred Names	Protein Names
inositol-pentakisphosphate 2-kinase	IPK1 homolog

Related Diseases

Diseases	Alias
Lethal Congenital Contracture Syndrome 1	LCCS1 Multiple Contracture Syndrome, Finnish Type Lccs Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures Lethal Congenital Contracture Syndrome Type 1 Herva Disease Multiple Contracture Syndrome Finnish Type Contracture Syndrome, Lethal, Congenital, Type 1
Spastic Paraplegia 63, Autosomal Recessive	SPG63 Hereditary Spastic Paraplegia 63 Spastic Paraplegia 63 Autosomal Recessive Spastic Paraplegia 63 Autosomal Recessive Spastic Paraplegia Type 63 Paraplegia, Spastic, Type 63, Autosomal Recessive
Lethal Congenital Contracture Syndrome	Lccs Lethal Congenital Contracture Syndrome 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06874	IPPK Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22210	Ippk Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	IPPK	VGNC	VGNC:73597
Mus musculus	IPPK	MGD	MGI:1922928
Rattus norvegicus	IPPK	RGD	RGD:1311271
Bos taurus	IPPK	VGNC	VGNC:56974
Canis familiaris	IPPK	VGNC	VGNC:42071
Others	IPPK	NCBI