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FNDC3B - fibronectin type III domain containing 3B Gene

Also Known as FAD104; PRO4979; YVTM2421

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64778

About FNDC3B

Cytogenetic location: 3q26.31 Genomic coordinates (GRCh38): 3:172,039,578-172,401,669 (from NCBI)

This gene has 12 transcripts (splice variants), 226 orthologues and 11 paralogues. Ubiquitous expression in placenta (RPKM 15.6), thyroid (RPKM 11.7) and 25 other tissues.

Summary

Enables RNA binding activity. Predicted to act upstream of or within several processes, including negative regulation of osteoblast differentiation; substrate adhesion-dependent cell spreading; and type II pneumocyte differentiation. Predicted to be located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

FNDC3B Products (2)

mRNA	Protein	Name
NM_001135095.2	NP_001128567.1	fibronectin type III domain-containing protein 3B
NM_022763.4	NP_073600.3	fibronectin type III domain-containing protein 3B

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FNDC3B Protein Structure

fn3

0
200
400
600
800
1000
1204 a.a.

Protein Preferred Names	Protein Names
fibronectin type III domain-containing protein 3B	HCV NS5A-binding protein 37

Related Diseases

Diseases	Alias
Urethra Clear Cell Adenocarcinoma	Clear Cell Adenocarcinoma Of The Urethra Urethral Clear Cell Adenocarcinoma
Urethra Adenocarcinoma	Adenocarcinoma Of The Urethra Urethral Adenocarcinoma
Keratoconus	Kc Conical Cornea Noninflammatory Corneal Thining Bulging Cornea Cornea Conical Acquired Conus Of Cornea
Irregular Astigmatism
Urethra Cancer	Cancer Of Urethra Malignant Tumour Of Urethra Malignant Urethral Neoplasm Urethral Ca
Corneal Ectasia
Gastric Tubular Adenocarcinoma	Tubular Adenocarcinoma Of Stomach
Glaucoma, Primary Open Angle	Glaucoma 1, Open Angle, E Primary Open Angle Glaucoma POAG Adult-Onset Primary Open Angle Glaucoma Chronic Simple Glaucoma GLC1E Primary Open Angle Glaucoma 1e Glaucoma, Open Angle, Primary
Fuchs' Endothelial Dystrophy	Fuchs Endothelial Corneal Dystrophy Fuchs Endothelial Dystrophy Fuchs Dystrophy Fced Fuchs' Corneal Dystrophy Fuchs' Endothelial Corneal Dystrophy Fuchs Atrophy Fuchs Corneal Dystrophy Endoepithelial Corneal Dystrophy Fecd Late Hereditary Endothelial Dystrophy Corneal Dystrophy, Fuchs Endothelial Dystrophy, Corneal, Fuchs Endothelial Corneal Dystrophy, Fuchs' Endothelial, 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05020	FNDC3B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	FNDC3B	VGNC	VGNC:29063
Felis catus	FNDC3B	VGNC	VGNC:62320
Rattus norvegicus	FNDC3B	RGD	RGD:1311673
Mus musculus	FNDC3B	MGD	MGI:1919257
Canis familiaris	FNDC3B	VGNC	VGNC:40929
Macaca mulatta	FNDC3B	VGNC	VGNC:72564
Others	FNDC3B	NCBI