ST3GAL1 - ST3 beta-galactoside alpha-2,3-sialyltransferase 1 Gene

Also Known as ST3O; SIAT4A; SIATFL; ST3GalA; ST3GalIA; Gal-NAc6S; ST3GalA.1; ST3GalIA,1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6482

About ST3GAL1

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:133,454,848-133,571,887 (from NCBI)

This gene has 16 transcripts (splice variants), 437 orthologues and 14 paralogues. Broad expression in thyroid (RPKM 30.7), kidney (RPKM 13.0) and 22 other tissues.

Summary

The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates. The encoded protein is normally found in the Golgi but can be proteolytically processed to a soluble form. Correct glycosylation of the encoded protein may be critical to its Sialyltransferase activity. This protein, which is a member of Glycosyltransferase family 29, can use the same acceptor substrates as does Sialyltransferase 4B. Two transcript variants encoding the same protein have been found for this gene. Other transcript variants may exist, but have not been fully characterized yet. [provided by RefSeq, Jul 2008]

ST3GAL1 Products (2)

mRNA Protein Name
NM_003033.4 NP_003024.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1
NM_173344.3 NP_775479.1 CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-galactoside (CMP) alpha-2,3-sialyltransferase activity IDA
IDA: Inferred from direct assay
8027041 GOA
Biological Process GO Annotation Evidence References Source
involved in ganglioside biosynthetic process via lactosylceramide IDA
IDA: Inferred from direct assay
8027041 GOA
involved in protein sialylation IDA
IDA: Inferred from direct assay
8027041 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi medial cisterna membrane IDA
IDA: Inferred from direct assay
9182658 GOA
located in Golgi trans cisterna membrane IDA
IDA: Inferred from direct assay
9182658 GOA
located in trans-Golgi network membrane IDA
IDA: Inferred from direct assay
9182658 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ST3GAL1 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (80 - 339)

  • 0
  • 100
  • 200
  • 300
  • 340 a.a.
Protein Preferred Names Protein Names

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

  • Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase

Related Diseases

Diseases Alias
Puerperal Pulmonary Embolism

  • Obstetric Pulmonary Embolism
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-163548 SPP-002 Inhibitor 98.0% Unkown
HY-172888 SPP-037 Inhibitor / Unkown
HY-E70298 ST3 β-Gal α-2,3-Sialyltransferase 1 / Unkown
HY-RS13846 ST3GAL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20651 St3gal1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27162 St3gal1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris ST3GAL1 VGNC VGNC:46850
Macaca mulatta ST3GAL1 VGNC VGNC:77825
Rattus norvegicus ST3GAL1 RGD RGD:1309373
Bos taurus ST3GAL1 VGNC VGNC:35331
Mus musculus ST3GAL1 MGD MGI:98304
Felis catus ST3GAL1 VGNC VGNC:65719
Others ST3GAL1 NCBI