ST8SIA1 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Gene

Homo sapiens

Also known as GD3S; SIAT8; SIAT8A; SIAT8-A; ST8SiaI

Gene ID: 6489 | Gene type: protein coding

About ST8SIA1

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:22,193,391-22,334,707 (from NCBI)

This gene has 15 transcripts (splice variants), 210 orthologues and 5 paralogues. Broad expression in brain (RPKM 1.5), adrenal (RPKM 0.7) and 19 other tissues.

Summary

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2015]

ST8SIA1 Products(2)

mRNA	Protein	Name
NM_001304450.2	NP_001291379.1	alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 2
NM_003034.4	NP_003025.1	alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 1

ST8SIA1 Protein Structure

Glyco_transf_29

0
100
200
300
356 a.a.

Protein Preferred Names

Protein Names

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1

Recombinant ST8SIA1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71334	ST8SIA1 Protein, Human (HEK293, His)	Q92185 (Y49-S356)	≥95%

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13856	ST8SIA1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ST8SIA1	MGD	MGI:106011
Macaca mulatta	ST8SIA1	VGNC	VGNC:77830
Canis familiaris	ST8SIA1	VGNC	VGNC:46864
Bos taurus	ST8SIA1	VGNC	VGNC:49964
Rattus norvegicus	ST8SIA1	RGD	RGD:3679
Others	ST8SIA1	NCBI

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