ST8SIA1 - ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 Gene

Also Known as GD3S; SIAT8; SIAT8A; SIAT8-A; ST8SiaI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6489

About ST8SIA1

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:22,193,391-22,334,707 (from NCBI)

This gene has 15 transcripts (splice variants), 210 orthologues and 5 paralogues. Broad expression in brain (RPKM 1.5), adrenal (RPKM 0.7) and 19 other tissues.

Summary

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of Glycosyltransferase family 29. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2015]

ST8SIA1 Products (2)

mRNA Protein Name
NM_001304450.2 NP_001291379.1 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 2
NM_003034.4 NP_003025.1 alpha-N-acetylneuraminide alpha-2,8-sialyltransferase isoform 1

ST8SIA1 Protein Structure

Glyco_transf_29

Glyco_transf_29: Glycosyltransferase family 29 (sialyltransferase) (88 - 343)

  • 0
  • 100
  • 200
  • 300
  • 356 a.a.
Protein Preferred Names Protein Names

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase

  • ST8 alpha-N-acetylneuraminate alpha-2,8-sialyltransferase 1

ST8SIA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ST8SIA1 Q92185 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
Intra
ST8SIA1 Q92185 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
Intra
ST8SIA1 Q92185 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ST8SIA1 Proteins

Cat. No. Product Name Accession Purity
HY-P71334 ST8SIA1 Protein, Human (HEK293, His) Q92185 (Y49-S356) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Melanoma

  • Malignant Melanoma

  • Cutaneous Melanoma

  • Naevocarcinoma

  • Malignant Melanomas
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13856 ST8SIA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22047 St8sia1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus ST8SIA1 MGD MGI:106011
Macaca mulatta ST8SIA1 VGNC VGNC:77830
Canis familiaris ST8SIA1 VGNC VGNC:46864
Bos taurus ST8SIA1 VGNC VGNC:49964
Rattus norvegicus ST8SIA1 RGD RGD:3679
Others ST8SIA1 NCBI