Kcnd2 - potassium voltage-gated channel subfamily D member 2 Gene

Also Known as RK5; Kv4.2; Shal1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65180

Summary

Enables A-type (transient outward) Potassium Channel activity and voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential. Involved in several processes, including cellular response to hypoxia; cellular response to mechanical stimulus; and potassium ion transmembrane transport. Located in several cellular components, including T-tubule; neuronal cell body membrane; and perinuclear endoplasmic reticulum. Is integral component of plasma membrane. Part of voltage-gated Potassium Channel complex. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane. Orthologous to human KCND2 (potassium voltage-gated channel subfamily D member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnd2 Products (1)

mRNA Protein Name
NM_031730.2 NP_113918.2 potassium voltage-gated channel subfamily D member 2 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables A-type (transient outward) potassium channel activity IDA
IDA: Inferred from direct assay
1722463 RGD
enables A-type (transient outward) potassium channel activity IMP
IMP: Inferred from mutant phenotype
16123112 RGD
enables monoatomic ion channel activity IDA
IDA: Inferred from direct assay
10325948 RGD
enables potassium channel activity IDA
IDA: Inferred from direct assay
10325948 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
11805342 RGD
enables protein-containing complex binding IDA
IDA: Inferred from direct assay
14980206 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
1722463 RGD
enables voltage-gated potassium channel activity IMP
IMP: Inferred from mutant phenotype
16123112 RGD
Biological Process GO Annotation Evidence References Source
involved in action potential IMP
IMP: Inferred from mutant phenotype
16141270 RGD
involved in cardiac muscle cell action potential IMP
IMP: Inferred from mutant phenotype
9058605 RGD
involved in cellular response to hypoxia IDA
IDA: Inferred from direct assay
25352783 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
17293496 RGD
involved in cellular response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
17293496 RGD
involved in potassium ion transmembrane transport IDA
IDA: Inferred from direct assay
1722463 RGD
Cellular Component GO Annotation Evidence References Source
located in T-tubule IDA
IDA: Inferred from direct assay
10860776 RGD
located in caveola IDA
IDA: Inferred from direct assay
20224290 RGD
located in dendrite IDA
IDA: Inferred from direct assay
15356203 RGD
located in dendritic spine IDA
IDA: Inferred from direct assay
9070739 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17582333 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15736227 RGD
located in neuronal cell body membrane IDA
IDA: Inferred from direct assay
9070739 RGD
located in perinuclear endoplasmic reticulum IDA
IDA: Inferred from direct assay
12967630 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
1722463 RGD
located in plasma membrane IMP
IMP: Inferred from mutant phenotype
1722463 RGD
located in plasma membrane raft IDA
IDA: Inferred from direct assay
24793047 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
17582333 RGD
located in postsynaptic membrane IDA
IDA: Inferred from direct assay
9070739 RGD
part of potassium channel complex IDA
IDA: Inferred from direct assay
14980206 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
10860776 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
15356203 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium voltage-gated channel subfamily D member 2

  • potassium channel, voltage-gated Shal-related subfamily D, member 2

  • potassium voltage gated channel, Shal-related family, member 2

  • potassium voltage-gated channel, Shal-related subfamily, member 2

  • voltage-gated potassium channel subunit Kv4.2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07113 KCND2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21609 Kcnd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28127 Kcnd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Kcnd2 NCBI NCBI:3751