WNK2 - WNK lysine deficient protein kinase 2 Gene

Also Known as PRKWNK2; NY-CO-43; SDCCAG43; P/OKcl.13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65268

About WNK2

Cytogenetic location: 9q22.31 Genomic coordinates (GRCh38): 9:93,184,139-93,320,569 (from NCBI)

This gene has 15 transcripts (splice variants), 333 orthologues, 6 paralogues and is associated with 88 phenotypes. Broad expression in heart (RPKM 6.5), colon (RPKM 6.3) and 18 other tissues.

Summary

The protein encoded by this gene is a cytoplasmic serine-threonine kinase that belongs to the protein kinase superfamily. The protein plays an important role in the regulation of electrolyte homeostasis, cell signaling survival, and proliferation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

WNK2 Products (2)

mRNA Protein Name
NM_001282394.3 NP_001269323.1 serine/threonine-protein kinase WNK2 isoform 1
NM_006648.4 NP_006639.3 serine/threonine-protein kinase WNK2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
35044719 GOA
Biological Process GO Annotation Evidence References Source
involved in monoatomic ion homeostasis IMP
IMP: Inferred from mutant phenotype
21733846 GOA
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17667937 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
17667937 GOA
involved in positive regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
23797875 GOA
involved in positive regulation of sodium ion transmembrane transporter activity IMP
IMP: Inferred from mutant phenotype
21733846 GOA
involved in protein autophosphorylation IDA
IDA: Inferred from direct assay
17667937 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
21733846 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17667937 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNK2 Protein Structure

Pkinase

Pkinase: Protein kinase domain (200 - 453)

OSR1_C

OSR1_C: Oxidative-stress-responsive kinase 1 C-terminal domain (474 - 511)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2000
  • 2297 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase WNK2

  • antigen NY-CO-43

Related Diseases

Diseases Alias
Hypomagnesemia 4, Renal

  • Renal Hypomagnesemia 4

  • HOMG4

  • Hypomagnesemia, Renal, Normocalciuric

  • Hypomagnesemia 4

  • Renal Hypomagnesemia Normocalciuric

  • Hypomagnesemia, Type 4, Renal
Suprasellar Meningioma
Angiomatous Meningioma
Pseudohypoaldosteronism
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-100626 WNK463 Inhibitor 99.75% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus WNK2 RGD RGD:1307284
Canis familiaris WNK2 VGNC VGNC:54853
Mus musculus WNK2 MGD MGI:1922857
Macaca mulatta WNK2 VGNC VGNC:78961
Bos taurus WNK2 VGNC VGNC:36950
Others WNK2 NCBI