SPAG1 - sperm associated antigen 1 Gene

Homo sapiens

Also known as SP75; TPIS; CT140; CILD28; DNAAF13; HSD-3.8; HEL-S-268

Gene ID: 6674 | Gene type: protein coding

About SPAG1

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:100,158,038-100,241,904 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues, 18 paralogues and is associated with 3 phenotypes. Broad expression in colon (RPKM 8.4), testis (RPKM 7.5) and 22 other tissues.

Summary

The correlation of anti-sperm Antibodies with cases of unexplained infertility implicates a role for these Antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating Antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]

SPAG1 Products(3)

mRNA	Protein	Name
NM_001374321.1	NP_001361250.1	sperm-associated antigen 1
NM_003114.5	NP_003105.2	sperm-associated antigen 1
NM_172218.3	NP_757367.1	sperm-associated antigen 1

SPAG1 Protein Structure

TPR_11

TPR_1

TPR_11

TPR_1

TPR_11

TPR_1

RPAP3_C

0
200
400
600
800
926 a.a.

Protein Preferred Names

Protein Names

sperm-associated antigen 1

TPR-containing protein involved in spermatogenesis

Related Diseases

Diseases

Alias

Ciliary Dyskinesia, Primary, 28

Primary Ciliary Dyskinesia 28	CILD28
Primary Ciliary Dyskinesia 28 With Or Without Situs Inversus	Ciliary Dyskinesia, Primary, 28, With Or Without Situs Inversus
Ciliary Dyskinesia, Primary, 28, Without Situs Inversus	Dyskinesia, Ciliary, Primary, 28

Epilepsy, Nocturnal Frontal Lobe, 5

ENFL5	Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 5
Epilepsy Nocturnal Frontal Lobe, 5	Nocturnal Frontal Lobe Epilepsy 5
Epilepsy, Frontal Lobe, Nocturnal, Type 5

Primary Ciliary Dyskinesia

Immotile Cilia Syndrome	Kartagener Syndrome
Dextrocardia Bronchiectasis And Sinusitis	Pcd
Ciliary Motility Disorders	Ciliary Motility Disorder
Immotile Ciliary Syndrome	Ciliary Dyskinesia Primary
Ics	Polynesian Bronchiectasis
Dextrocardia-Bronchiectasis-Sinusitis Syndrome	Immotile Cilia Syndrome, Kartagener Type
Primary Ciliary Dyskinesia And Situs Inversus	Primary Ciliary Dyskinesia, Kartagener Type
Siewert Syndrome	Dyskinesia, Ciliary, Primary

Infertility

Theileriasis

Theileriosis

Infection By Theileria

Kartagener Syndrome

Kartagener'S Syndrome

Situs Inversus

Situs Inversus Viscerum	Laterality Sequence
Complete Transposition	Siv

Visceral Heterotaxy

Situs Ambiguus	Heterotaxia
Heterotaxy Syndrome	Heterotaxy
Lateralization Defect	Situs Ambiguous
Left Isomerism	Htx
Ivemark Syndrome	Right Isomerism
Situs Ambiguus Viscerum	Incomplete Situs Inversus
Partial Situs Inversus	Heterotaxy, Visceral
Asplenia Syndrome	Bilateral Left-Sidedness
Polysplenia Syndrome	Moller Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13620	SPAG1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SPAG1	MGD	MGI:1349387
Felis catus	SPAG1	VGNC	VGNC:65595
Macaca mulatta	SPAG1	VGNC	VGNC:77849
Bos taurus	SPAG1	VGNC	VGNC:35164
Rattus norvegicus	SPAG1	RGD	RGD:1310702
Others	SPAG1	NCBI

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