SPAG1 - sperm associated antigen 1 Gene

Also Known as SP75; TPIS; CT140; CILD28; DNAAF13; HSD-3.8; HEL-S-268

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6674

About SPAG1

Cytogenetic location: 8q22.2 Genomic coordinates (GRCh38): 8:100,158,038-100,241,904 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues, 18 paralogues and is associated with 3 phenotypes. Broad expression in colon (RPKM 8.4), testis (RPKM 7.5) and 22 other tissues.

Summary

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]

SPAG1 Products (3)

mRNA Protein Name
NM_001374321.1 NP_001361250.1 sperm-associated antigen 1
NM_003114.5 NP_003105.2 sperm-associated antigen 1
NM_172218.3 NP_757367.1 sperm-associated antigen 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16983343 GOA
part of protein folding chaperone complex IPI
IPI: Inferred from physical interaction
29844425 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPAG1 Protein Structure

TPR_11

TPR_11: TPR repeat (212 - 273)

TPR_1

TPR_1: Tetratricopeptide repeat (276 - 309)

TPR_11

TPR_11: TPR repeat (445 - 518)

TPR_1

TPR_1: Tetratricopeptide repeat (524 - 551)

TPR_11

TPR_11: TPR repeat (624 - 687)

TPR_1

TPR_1: Tetratricopeptide repeat (691 - 723)

RPAP3_C

RPAP3_C: Potential Monad-binding region of RPAP3 (802 - 895)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 926 a.a.
Protein Preferred Names Protein Names

sperm-associated antigen 1

  • TPR-containing protein involved in spermatogenesis

Related Diseases

Diseases Alias
Ciliary Dyskinesia, Primary, 28

  • Primary Ciliary Dyskinesia 28

  • CILD28

  • Primary Ciliary Dyskinesia 28 With Or Without Situs Inversus

  • Ciliary Dyskinesia, Primary, 28, With Or Without Situs Inversus

  • Ciliary Dyskinesia, Primary, 28, Without Situs Inversus

  • Dyskinesia, Ciliary, Primary, 28
Epilepsy, Nocturnal Frontal Lobe, 5

  • ENFL5

  • Autosomal Dominant Nocturnal Frontal Lobe Epilepsy 5

  • Epilepsy Nocturnal Frontal Lobe, 5

  • Nocturnal Frontal Lobe Epilepsy 5

  • Epilepsy, Frontal Lobe, Nocturnal, Type 5
Primary Ciliary Dyskinesia

  • Immotile Cilia Syndrome

  • Kartagener Syndrome

  • Dextrocardia Bronchiectasis And Sinusitis

  • Pcd

  • Ciliary Motility Disorders

  • Ciliary Motility Disorder

  • Immotile Ciliary Syndrome

  • Ciliary Dyskinesia Primary

  • Ics

  • Polynesian Bronchiectasis

  • Dextrocardia-Bronchiectasis-Sinusitis Syndrome

  • Immotile Cilia Syndrome, Kartagener Type

  • Primary Ciliary Dyskinesia And Situs Inversus

  • Primary Ciliary Dyskinesia, Kartagener Type

  • Siewert Syndrome

  • Dyskinesia, Ciliary, Primary
Infertility
Theileriasis

  • Theileriosis

  • Infection By Theileria
Kartagener Syndrome

  • Kartagener'S Syndrome
Situs Inversus

  • Situs Inversus Viscerum

  • Laterality Sequence

  • Complete Transposition

  • Siv
Visceral Heterotaxy

  • Situs Ambiguus

  • Heterotaxia

  • Heterotaxy Syndrome

  • Heterotaxy

  • Lateralization Defect

  • Situs Ambiguous

  • Left Isomerism

  • Htx

  • Ivemark Syndrome

  • Right Isomerism

  • Situs Ambiguus Viscerum

  • Incomplete Situs Inversus

  • Partial Situs Inversus

  • Heterotaxy, Visceral

  • Asplenia Syndrome

  • Bilateral Left-Sidedness

  • Polysplenia Syndrome

  • Moller Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13620 SPAG1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18685 Spag1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25171 Spag1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus SPAG1 MGD MGI:1349387
Felis catus SPAG1 VGNC VGNC:65595
Macaca mulatta SPAG1 VGNC VGNC:77849
Bos taurus SPAG1 VGNC VGNC:35164
Rattus norvegicus SPAG1 RGD RGD:1310702
Others SPAG1 NCBI