Pnpla2 - patatin-like phospholipase domain containing 2 Gene

Also Known as Atgl; TTS-2.2; 0610039C21Rik; 1110001C14Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66853

About Pnpla2

Chromosome 7: 141,035,111-141,040,656 forward strand.GRCm39:CM001000.3

This gene has 7 transcripts (splice variants), 193 orthologues, 3 paralogues and is associated with 59 phenotypes. Biased expression in mammary gland adult (RPKM 647.4), subcutaneous fat pad adult (RPKM 559.9) and 14 other tissues.

Summary

Enables triglyceride Lipase activity. Involved in several processes, including acylglycerol metabolic process; negative regulation of sequestering of triglyceride; and positive regulation of triglyceride catabolic process. Acts upstream of or within cellular lipid catabolic process and lipid droplet organization. Located in cytosol and lipid droplet. Orthologous to human PNPLA2 (patatin like Phospholipase domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]

Pnpla2 Products (2)

mRNA Protein Name
NM_025802.3 NP_080078.2 patatin-like phospholipase domain-containing protein 2 isoform 2
NM_001163689.1 NP_001157161.1 patatin-like phospholipase domain-containing protein 2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16679289 MGI
enables triacylglycerol lipase activity IDA
IDA: Inferred from direct assay
15337759 MGI
enables triacylglycerol lipase activity IMP
IMP: Inferred from mutant phenotype
16675698 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cellular lipid catabolic process IMP
IMP: Inferred from mutant phenotype
26427354 MGI
involved in diacylglycerol biosynthetic process IDA
IDA: Inferred from direct assay
23066022 MGI
acts upstream of or within lipid droplet organization IMP
IMP: Inferred from mutant phenotype
23297223 MGI
involved in lipid storage IMP
IMP: Inferred from mutant phenotype
21148142 MGI
involved in negative regulation of sequestering of triglyceride IDA
IDA: Inferred from direct assay
16679289 MGI
involved in positive regulation of triglyceride catabolic process IDA
IDA: Inferred from direct assay
16679289 MGI
involved in triglyceride catabolic process IDA
IDA: Inferred from direct assay
23066022 MGI
acts upstream of or within triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
17074755 MGI
involved in triglyceride catabolic process IMP
IMP: Inferred from mutant phenotype
16675698 MGI
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
15337759 MGI
located in cytosol IDA
IDA: Inferred from direct assay
17074755 MGI
located in lipid droplet IDA
IDA: Inferred from direct assay
15550674 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pnpla2 Protein Structure

Pat_PNPLA2

Pat_PNPLA2: cd07220 (3 - 251)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 486 a.a.
Protein Preferred Names Protein Names

patatin-like phospholipase domain-containing protein 2

  • adipose triglyceride lipase

  • calcium-independent phospholipase A2-zeta

  • desnutrin

  • iPLA2-zeta

  • transport-secretion protein

  • triglyceride hydrolase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10791 PNPLA2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10792 Pnpla2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10793 PNPLA2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pnpla2 NCBI NCBI:57104