Cltc - clathrin, heavy polypeptide (Hc) Gene

Also Known as CHC; 3110065L21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67300

Summary

Enables protein kinase binding activity. Predicted to be involved in several processes, including amyloid-beta clearance by transcytosis; endocytosis; and negative regulation of hyaluronan biosynthetic process. Predicted to act upstream of or within mitotic spindle assembly. Located in clathrin-coated pit and photoreceptor ribbon synapse. Part of membrane coat. Is active in presynaptic endocytic zone membrane. Is expressed in 8-cell stage embryo; brain; placenta; and unsegmented mesenchyme. Human ortholog(s) of this gene implicated in autosomal dominant mental retardation 56. Orthologous to human CLTC (clathrin heavy chain). [provided by Alliance of Genome Resources, Apr 2022]

Cltc Products (2)

mRNA Protein Name
NM_001003908.2 NP_001003908.1 clathrin heavy chain 1 isoform 2
NM_001356393.1 NP_001343322.1 clathrin heavy chain 1 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23746204 MGI
enables protein kinase binding IPI
IPI: Inferred from physical interaction
21307259 MGI
Cellular Component GO Annotation Evidence References Source
located in clathrin-coated pit IDA
IDA: Inferred from direct assay
26437238 MGI
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
17028301 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
17028301 MGI
located in membrane IMP
IMP: Inferred from mutant phenotype
20080761 MGI
part of membrane coat IDA
IDA: Inferred from direct assay
11879655 MGI
is active in photoreceptor ribbon synapse IDA
IDA: Inferred from direct assay
23785143 MGI
is active in postsynaptic endocytic zone EXP
EXP: Inferred from Experiment
17028301 MGI
is active in postsynaptic endocytic zone IDA
IDA: Inferred from direct assay
17028301 MGI
is active in presynaptic endocytic zone membrane IDA
IDA: Inferred from direct assay
23785143 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

clathrin heavy chain 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02845 CLTC Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21314 Cltc Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27833 Cltc Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cltc NCBI NCBI:1213