Pkp2 - plakophilin 2 Gene

Also Known as Pkp2l; 1200008D14Rik; 1200012P04Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67451

Summary

Predicted to enable several functions, including alpha-catenin binding activity; Cadherin binding activity; and protein kinase C binding activity. Acts upstream of or within cell-cell adhesion and heart development. Located in desmosome; intercalated disc; and intermediate filament. Is expressed in brain; cardiac muscle tissue; and telencephalon. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy and arrhythmogenic right ventricular dysplasia 9. Orthologous to human PKP2 (plakophilin 2). [provided by Alliance of Genome Resources, Apr 2022]

Pkp2 Products (1)

mRNA Protein Name
NM_026163.2 NP_080439.1 plakophilin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17535849 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15479741 MGI
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
15479741 MGI
involved in maintenance of protein localization at cell tip IMP
IMP: Inferred from mutant phenotype
35959657 MGI
Cellular Component GO Annotation Evidence References Source
located in cell-cell junction IDA
IDA: Inferred from direct assay
21296051 MGI
located in cell-cell junction IMP
IMP: Inferred from mutant phenotype
15479741 MGI
located in desmosome IDA
IDA: Inferred from direct assay
9864371 MGI
located in intercalated disc IDA
IDA: Inferred from direct assay
17535849 MGI
located in intermediate filament IDA
IDA: Inferred from direct assay
16917092 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plakophilin-2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10612 PKP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20326 Pkp2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26834 Pkp2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pkp2 NCBI NCBI:5318