Abhd5 - abhydrolase domain containing 5 Gene

Also Known as IECN5; NCIE2; CGI-58; 1300003D03Rik; 2010002J10Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67469

Summary

Predicted to enable 1-acylglycerol-3-phosphate O-acyltransferase activity and carboxylic ester hydrolase activity. Involved in negative regulation of sequestering of triglyceride and positive regulation of triglyceride catabolic process. Acts upstream of or within positive regulation of lipoprotein Lipase activity. Located in cytosol and lipid droplet. Is expressed in central nervous system; dorsal root ganglion; epidermis; and retina. Used to study neutral lipid storage disease. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 1 and neutral lipid storage disease. Orthologous to human ABHD5 (abhydrolase domain containing 5, lysophosphatidic acid Acyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Abhd5 Products (4)

mRNA Protein Name
NM_001359207.1 NP_001346136.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 2
NM_026179.2 NP_080455.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 1
NM_001359207.1 NP_001346136.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 2
NM_026179.2 NP_080455.1 1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables lipase activator activity IDA
IDA: Inferred from direct assay
17074755 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
16679289 MGI
NOT enables triacylglycerol lipase activity IDA
IDA: Inferred from direct assay
16679289 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of sequestering of triglyceride IDA
IDA: Inferred from direct assay
16679289 MGI
involved in positive regulation of lipid catabolic process IMP
IMP: Inferred from mutant phenotype
22383684 MGI
involved in positive regulation of triglyceride catabolic process IDA
IDA: Inferred from direct assay
16679289 MGI
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
18606822 MGI
located in lipid droplet IDA
IDA: Inferred from direct assay
18606822 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

1-acylglycerol-3-phosphate O-acyltransferase ABHD5

  • abhydrolase domain-containing protein 5

  • lipid droplet-binding protein CGI-58

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-111952 SR-4995 98.26% Unkown
HY-111953 SR-4559 98.81% Unkown
HY-RS00096 ABHD5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20356 Abhd5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26865 Abhd5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abhd5 NCBI NCBI:51099