Abcg8 - ATP binding cassette subfamily G member 8 Gene

Also Known as sterolin-2; 1300003C16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67470

Summary

Enables protein heterodimerization activity. Contributes to Cholesterol transfer activity. Involved in Cholesterol efflux and excretion. Acts upstream of or within Cholesterol homeostasis and phospholipid transport. Located in apical plasma membrane. Is integral component of plasma membrane. Part of receptor complex. Is expressed in several structures, including Peyer's patch; alimentary system; brain; liver and biliary system; and thymus. Used to study sitosterolemia. Human ortholog(s) of this gene implicated in arteriosclerosis; familial hyperlipidemia; gallbladder disease; obesity; and sitosterolemia. Orthologous to human ABCG8 (ATP binding cassette subfamily G member 8). [provided by Alliance of Genome Resources, Apr 2022]

Abcg8 Products (3)

mRNA Protein Name
NM_001286005.1 NP_001272934.1 ATP-binding cassette sub-family G member 8 isoform 2
NM_001347418.1 NP_001334347.1 ATP-binding cassette sub-family G member 8 isoform 3
NM_026180.3 NP_080456.1 ATP-binding cassette sub-family G member 8 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
contributes to cholesterol transfer activity IMP
IMP: Inferred from mutant phenotype
14504269 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
12208867 MGI
enables protein heterodimerization activity IDA
IDA: Inferred from direct assay
12208867 MGI
Biological Process GO Annotation Evidence References Source
involved in cholesterol efflux IMP
IMP: Inferred from mutant phenotype
14504269 MGI
acts upstream of or within cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
15040800 MGI
acts upstream of or within phospholipid transport IMP
IMP: Inferred from mutant phenotype
15040800 MGI
acts upstream of or within sterol homeostasis IMP
IMP: Inferred from mutant phenotype
15040800 MGI
involved in sterol transport IDA
IDA: Inferred from direct assay
16867993 MGI
acts upstream of or within sterol transport IMP
IMP: Inferred from mutant phenotype
15040800 MGI
Cellular Component GO Annotation Evidence References Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
12208867 MGI
located in apical plasma membrane IMP
IMP: Inferred from mutant phenotype
14504269 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
12208867 MGI
part of receptor complex IDA
IDA: Inferred from direct assay
14504269 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-binding cassette sub-family G member 8

  • ATP-binding cassette, sub-family G (WHITE), member 8

  • sterolin 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0288 Lycorine 99.98% Unkown
HY-N0288R Lycorine (Standard) 99.54% Unkown
HY-RS00082 ABCG8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-181520 ABCA1 inducer 3 Inducer / Unkown
HY-RS18052 Abcg8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24526 Abcg8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Abcg8 NCBI NCBI:64241