Plxnd1 - plexin D1 Gene

Also Known as b2b553Clo; b2b1863Clo; 6230425C21Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67784

Summary

Enables semaphorin receptor activity. Involved in several processes, including endothelial cell migration; semaphorin-plexin signaling pathway; and synapse assembly. Acts upstream of or within several processes, including circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and positive regulation of protein binding activity. Is integral component of plasma membrane. Is expressed in several structures, including cardiovascular system; genitourinary system; liver; nervous system; and spleen. Used to study DiGeorge syndrome. Orthologous to human PLXND1 (plexin D1). [provided by Alliance of Genome Resources, Apr 2022]

Plxnd1 Products (1)

mRNA Protein Name
NM_026376.4 NP_080652.2 plexin-D1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15239958 MGI
enables semaphorin receptor activity IDA
IDA: Inferred from direct assay
17318185 MGI
enables semaphorin receptor activity IMP
IMP: Inferred from mutant phenotype
25985275 MGI
enables semaphorin receptor activity IPI
IPI: Inferred from physical interaction
15239958 MGI
Biological Process GO Annotation Evidence References Source
involved in angiogenesis IMP
IMP: Inferred from mutant phenotype
18992737 MGI
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within branching involved in blood vessel morphogenesis IMP
IMP: Inferred from mutant phenotype
15239958 MGI
acts upstream of or within cardiac septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within dichotomous subdivision of terminal units involved in salivary gland branching IDA
IDA: Inferred from direct assay
17626059 MGI
involved in endothelial cell migration IMP
IMP: Inferred from mutant phenotype
18992737 MGI
acts upstream of or within kidney development IMP
IMP: Inferred from mutant phenotype
27002738 MGI
involved in negative regulation of neuron apoptotic process IMP
IMP: Inferred from mutant phenotype
25985275 MGI
acts upstream of or within outflow tract morphogenesis IMP
IMP: Inferred from mutant phenotype
23918385 MGI
acts upstream of or within positive regulation of protein binding IDA
IDA: Inferred from direct assay
15239958 MGI
involved in regulation of angiogenesis IMP
IMP: Inferred from mutant phenotype
17318185 MGI
involved in regulation of cell migration IMP
IMP: Inferred from mutant phenotype
17318185 MGI
acts upstream of or within semaphorin-plexin signaling pathway IGI
IGI: Inferred from genetic interaction
15239958 MGI
involved in semaphorin-plexin signaling pathway IGI
IGI: Inferred from genetic interaction
25985275 MGI
involved in semaphorin-plexin signaling pathway IMP
IMP: Inferred from mutant phenotype
17318185 MGI
involved in synapse assembly IMP
IMP: Inferred from mutant phenotype
22179111 MGI
involved in synaptic target recognition IDA
IDA: Inferred from direct assay
22179111 MGI
involved in synaptic target recognition IMP
IMP: Inferred from mutant phenotype
22179111 MGI
Cellular Component GO Annotation Evidence References Source
located in axon IDA
IDA: Inferred from direct assay
25985275 MGI
located in cell body IDA
IDA: Inferred from direct assay
25985275 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
22179111 MGI
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
22179111 MGI
located in plasma membrane IDA
IDA: Inferred from direct assay
17318185 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

plexin-D1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10756 PLXND1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20190 Plxnd1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26694 Plxnd1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Plxnd1 NCBI NCBI:23129