Atp2b1 - ATPase, Ca++ transporting, plasma membrane 1 Gene

Also Known as Pmca1; 2810442I22Rik; E130111D10Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 67972

Summary

Predicted to enable P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration and PDZ domain binding activity. Involved in several processes, including negative regulation of cytosolic calcium ion concentration; positive regulation of bone mineralization; and regulation of vascular associated smooth muscle contraction. Located in basolateral plasma membrane and immunological synapse. Is integral component of presynaptic membrane and integral component of synaptic vesicle membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human ATP2B1 (ATPase plasma membrane Ca2+ transporting 1). [provided by Alliance of Genome Resources, Apr 2022]

Atp2b1 Products (5)

mRNA	Protein	Name
NM_001359506.1	NP_001346435.1	plasma membrane calcium-transporting ATPase 1 isoform 1
NM_001359507.1	NP_001346436.1	plasma membrane calcium-transporting ATPase 1 isoform 3
NM_001359508.1	NP_001346437.1	plasma membrane calcium-transporting ATPase 1 isoform 3
NM_001359509.1	NP_001346438.1	plasma membrane calcium-transporting ATPase 1 isoform 4
NM_026482.2	NP_080758.1	plasma membrane calcium-transporting ATPase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16352659	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular calcium ion homeostasis	IMP IMP: Inferred from mutant phenotype	16956963	MGI
involved in negative regulation of cytokine production	IMP IMP: Inferred from mutant phenotype	28827723	MGI
involved in negative regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	22311909	MGI
involved in positive regulation of bone mineralization	IMP IMP: Inferred from mutant phenotype	26392310	MGI
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	26392310	MGI
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	22311909	MGI
involved in regulation of cytosolic calcium ion concentration	IMP IMP: Inferred from mutant phenotype	24805951	MGI
involved in regulation of vascular associated smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	24805951	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	23460639	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	19233278	MGI
located in immunological synapse	IDA IDA: Inferred from direct assay	28827723	MGI
is active in photoreceptor ribbon synapse	IDA IDA: Inferred from direct assay	19233278	MGI
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	19233278	MGI
located in presynaptic membrane	IDA IDA: Inferred from direct assay	30862855	MGI
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	30862855	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
plasma membrane calcium-transporting ATPase 1	plasma membrane calcium ATPase plasma membrane calcium pump

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01194	ATP2B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20524	Atp2b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27033	Atp2b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp2b1	NCBI	NCBI:490