Atad1 - ATPase family, AAA domain containing 1 Gene

Also Known as Thorase; 4921525H23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 67979

Summary

Predicted to enable ATP binding activity and ATP hydrolysis activity. Involved in learning or memory; negative regulation of glutamatergic synaptic transmission; and regulation of receptor internalization. Located in postsynaptic membrane. Is active in glutamatergic synapse and postsynapse. Is expressed in central nervous system; ganglia; renal cortex; submandibular gland primordium; and thymus primordium. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]

Atad1 Products (1)

mRNA	Protein	Name
NM_026487.3	NP_080763.2	outer mitochondrial transmembrane helix translocase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP hydrolysis activity	IDA IDA: Inferred from direct assay	21496646	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21496646	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in learning	IMP IMP: Inferred from mutant phenotype	21496646	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	21496646	MGI
involved in negative regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	21496646	MGI
involved in positive regulation of receptor internalization	IMP IMP: Inferred from mutant phenotype	21496646	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	21496646	MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	21496646	MGI

Cellular Component GO Annotation	Evidence	References	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21496646	MGI
is active in glutamatergic synapse	IEP IEP: Inferred from expression pattern	21496646	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	21496646	MGI
is active in postsynapse	IDA IDA: Inferred from direct assay	21496646	MGI
is active in postsynapse	IEP IEP: Inferred from expression pattern	21496646	MGI
located in postsynaptic membrane	IDA IDA: Inferred from direct assay	21496646	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
outer mitochondrial transmembrane helix translocase ATPase family AAA domain-containing protein 1

Protein Preferred Names

Protein Names

outer mitochondrial transmembrane helix translocase

ATPase family AAA domain-containing protein 1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10326	Z-ATAD-FMK	Inhibitor	/	Unkown
HY-RS01118	ATAD1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21487	Atad1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28005	Atad1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atad1	NCBI	NCBI:84896