TAF4B - TATA-box binding protein associated factor 4b Gene

Also Known as SPGF13; TAF2C2; TAFII105

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6875

About TAF4B

Cytogenetic location: 18q11.2 Genomic coordinates (GRCh38): 18:26,226,445-26,391,685 (from NCBI)

This gene has 3 transcripts (splice variants), 184 orthologues, 1 paralogue and is associated with 2 phenotypes. Broad expression in testis (RPKM 5.0), lymph node (RPKM 3.4) and 24 other tissues.

Summary

TATA binding protein (TBP) and TBP-associated factors (TAFs) participate in the formation of the TFIID protein complex, which is involved in initiation of transcription of genes by RNA polymerase II. This gene encodes a cell type-specific TAF that may be responsible for mediating transcription by a subset of activators in B cells. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

TAF4B Products (2)

mRNA	Protein	Name
NM_001293725.2	NP_001280654.1	transcription initiation factor TFIID subunit 4B isoform 1
NM_005640.3	NP_005631.1	transcription initiation factor TFIID subunit 4B isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	15601843	GOA
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	10849440	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	29111974	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF4B Protein Structure

TAFH

TAF4

0
200
400
600
800
862 a.a.

Protein Preferred Names	Protein Names
transcription initiation factor TFIID subunit 4B	TAF(II)105

Related Diseases

Diseases	Alias
Spermatogenic Failure 13	SPGF13
Male Infertility With Azoospermia Or Oligozoospermia Due To Single Gene Mutation
Spermatogenic Failure	Azoospermia Spgf Spermatogenic Failure, Susceptibility To Absent Sperm Aspermatogenesis Infertility Due To Azoospermia Hypospermatogenesis Azoospermatism
Male Infertility	Infertility, Male Infertility Male Male Sterility Absolute Infertility
Vas Deferens, Congenital Bilateral Aplasia Of	Congenital Bilateral Absence Of Vas Deferens CBAVD Cavd Congenital Bilateral Aplasia Of Vas Deferens Congenital Bilateral Absence Of The Vas Deferens Congenital Bilateral Agenesis Of Vas Deferens Absence Of Vas Deferens Absent Vasa Congenital Absence Of Vas Deferens Congenital Aplasia Of Vas Deferens Absent Vas Deferens Vas Deferens, Congenital Bilateral Absence

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14170	TAF4B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TAF4B	RGD	RGD:1562997
Felis catus	TAF4B	VGNC	VGNC:65932
Bos taurus	TAF4B	VGNC	VGNC:35575
Canis familiaris	TAF4B	VGNC	VGNC:47082
Mus musculus	TAF4B	MGD	MGI:2152345
Macaca mulatta	TAF4B	VGNC	VGNC:78091
Others	TAF4B	NCBI