TCP11 - t-complex 11 Gene

Also Known as FPPR; D6S230E

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6954

About TCP11

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,118,075-35,141,339 (from NCBI)

This gene has 29 transcripts (splice variants), 93 orthologues and 4 paralogues. Restricted expression toward testis (RPKM 154.9).

Summary

Predicted to be involved in several processes, including protein kinase A signaling; regulation of cAMP-mediated signaling; and regulation of sperm capacitation. Located in acrosomal vesicle and sperm flagellum. [provided by Alliance of Genome Resources, Apr 2022]

TCP11 Products (17)

mRNA Protein Name
NM_001261817.2 NP_001248746.2 T-complex protein 11 homolog isoform 3
NM_001261818.2 NP_001248747.1 T-complex protein 11 homolog isoform 4
NM_001261819.2 NP_001248748.1 T-complex protein 11 homolog isoform 5
NM_001261820.2 NP_001248749.1 T-complex protein 11 homolog isoform 6
NM_001261821.2 NP_001248750.1 T-complex protein 11 homolog isoform 6
NM_001366323.2 NP_001353252.1 T-complex protein 11 homolog isoform 6
NM_001366324.2 NP_001353253.1 T-complex protein 11 homolog isoform 2
NM_001366325.2 NP_001353254.1 T-complex protein 11 homolog isoform 7
NM_001366326.2 NP_001353255.1 T-complex protein 11 homolog isoform 8
NM_001366327.2 NP_001353256.1 T-complex protein 11 homolog isoform 9
NM_001366328.2 NP_001353257.1 T-complex protein 11 homolog isoform 9
NM_001366329.2 NP_001353258.1 T-complex protein 11 homolog isoform 9
NM_001366330.2 NP_001353259.1 T-complex protein 11 homolog isoform 10
NM_001366331.2 NP_001353260.1 T-complex protein 11 homolog isoform 11
NM_001366332.2 NP_001353261.1 T-complex protein 11 homolog isoform 12
NM_001370687.1 NP_001357616.1 T-complex protein 11 homolog isoform 1
NM_018679.6 NP_061149.1 T-complex protein 11 homolog isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21597245 GOA
Biological Process GO Annotation Evidence References Source
involved in germ cell development IEP
IEP: Inferred from expression pattern
1893875 GOA
Cellular Component GO Annotation Evidence References Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
21597245 GOA
located in sperm flagellum IDA
IDA: Inferred from direct assay
21597245 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCP11 Protein Structure

Tcp11

Tcp11: T-complex protein 11 (58 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 503 a.a.
Protein Preferred Names Protein Names

T-complex protein 11 homolog

  • fertilization-promoting peptide receptor

Related Diseases

Diseases Alias
Pelvic Varices

  • Varix Of Pelvis

  • Pelvic Varicose Vein
Spermatogenic Failure

  • Azoospermia

  • Spgf

  • Spermatogenic Failure, Susceptibility To

  • Absent Sperm

  • Aspermatogenesis

  • Infertility Due To Azoospermia

  • Hypospermatogenesis

  • Azoospermatism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14322 TCP11 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14323 TCP11L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS14324 TCP11L2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris TCP11 VGNC VGNC:47208
Mus musculus TCP11 MGD MGI:98544
Macaca mulatta TCP11 VGNC VGNC:78295
Bos taurus TCP11 VGNC VGNC:35702
Rattus norvegicus TCP11 RGD RGD:1359387
Felis catus TCP11 VGNC VGNC:66035
Others TCP11 NCBI