Prdm16 - PR domain containing 16 Gene

Also Known as csp1; mel1; 5730557K01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70673

Summary

Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; Histone Methyltransferase activity (H3-K9 specific); and transcription coactivator activity. Involved in several processes, including brown fat cell differentiation; positive regulation of cold-induced thermogenesis; and regulation of transcription, DNA-templated. Acts upstream of or within several processes, including negative regulation of transforming growth factor beta receptor signaling pathway; positive regulation of brown fat cell differentiation; and tongue development. Located in nucleus. Part of transcription repressor complex. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; embryo mesenchyme; and sensory organ. Orthologous to human PRDM16 (PR/SET domain 16). [provided by Alliance of Genome Resources, Apr 2022]

Prdm16 Products (4)

mRNA Protein Name
NM_001177995.1 NP_001171466.1 histone-lysine N-methyltransferase PRDM16 isoform 2
NM_001291026.1 NP_001277955.1 histone-lysine N-methyltransferase PRDM16 isoform 3
NM_001291029.1 NP_001277958.1 histone-lysine N-methyltransferase PRDM16 isoform 4
NM_027504.3 NP_081780.3 histone-lysine N-methyltransferase PRDM16 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
28930673 MGI
enables SMAD binding IPI
IPI: Inferred from physical interaction
17467076 MGI
enables histone H3K9 methyltransferase activity IDA
IDA: Inferred from direct assay
22939622 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
17467076 MGI
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
17618855 MGI
enables transcription coactivator activity IDA
IDA: Inferred from direct assay
17618855 MGI
Biological Process GO Annotation Evidence References Source
involved in brown fat cell differentiation IDA
IDA: Inferred from direct assay
18483224 MGI
acts upstream of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
24703692 MGI
involved in brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
17618855 MGI
involved in heterochromatin organization IMP
IMP: Inferred from mutant phenotype
22939622 MGI
involved in negative regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18483224 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: Inferred from mutant phenotype
24703692 MGI
acts upstream of or within negative regulation of transforming growth factor beta receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
20007998 MGI
acts upstream of or within neurogenesis IDA
IDA: Inferred from direct assay
19050759 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
28930673 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
18483224 MGI
acts upstream of or within positive regulation of brown fat cell differentiation IMP
IMP: Inferred from mutant phenotype
24703692 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24439384 MGI
involved in regulation of cellular respiration IDA
IDA: Inferred from direct assay
17618855 MGI
acts upstream of or within roof of mouth development IMP
IMP: Inferred from mutant phenotype
20007998 MGI
acts upstream of or within somatic stem cell population maintenance IDA
IDA: Inferred from direct assay
19379700 MGI
acts upstream of or within stem cell population maintenance IGI
IGI: Inferred from genetic interaction
24703692 MGI
acts upstream of or within stem cell population maintenance IMP
IMP: Inferred from mutant phenotype
24703692 MGI
acts upstream of or within tongue development IMP
IMP: Inferred from mutant phenotype
20007998 MGI
involved in white fat cell differentiation IDA
IDA: Inferred from direct assay
18483224 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
18483224 MGI
part of transcription repressor complex IDA
IDA: Inferred from direct assay
18483224 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

histone-lysine N-methyltransferase PRDM16

  • MDS1/EVI1-like gene 1

  • PR domain zinc finger protein 16

  • PR domain-containing protein 16

  • line 27

  • transcription factor MEL1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-177467 P0064 98.0% Unkown
HY-119790 Palmitoyllactic acid Agonist 99.89% Unkown
HY-RS11066 PRDM16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19522 Prdm16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26017 Prdm16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Prdm16 NCBI NCBI:63976