Ubr5 - ubiquitin protein ligase E3 component n-recognin 5 Gene

Also Known as Edd; Edd1

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70790

Summary

Predicted to enable protein domain specific binding activity and ubiquitin-ubiquitin Ligase activity. Acts upstream of or within negative regulation of interleukin-17 production and regulation of protein stability. Predicted to be located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleus. Is expressed in cranial ganglion; nervous system; sensory organ; submandibular gland primordium; and vibrissa. Human ortholog(s) of this gene implicated in invasive ductal carcinoma. Orthologous to human UBR5 (ubiquitin protein Ligase E3 component n-recognin 5). [provided by Alliance of Genome Resources, Apr 2022]

Ubr5 Products (2)

mRNA Protein Name
NM_001081359.3 NP_001074828.2 E3 ubiquitin-protein ligase UBR5 isoform 1
NM_001112721.2 NP_001106192.1 E3 ubiquitin-protein ligase UBR5 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25470037 MGI
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19008229 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of interleukin-17 production IGI
IGI: Inferred from genetic interaction
25470037 MGI
involved in negative regulation of smoothened signaling pathway IMP
IMP: Inferred from mutant phenotype
27299863 MGI
acts upstream of or within regulation of protein stability IMP
IMP: Inferred from mutant phenotype
25470037 MGI
involved in ubiquitin-dependent protein catabolic process via the N-end rule pathway IDA
IDA: Inferred from direct assay
16055722 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase UBR5

  • E3 ubiquitin-protein ligase, HECT domain-containing 1

  • HECT-type E3 ubiquitin transferase UBR5

  • extraembryonic development

  • hyperplastic discs protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15390 UBR5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-168869 Tamoxifen-PEG-Clozapine Degrader / Unkown
HY-RS18504 Ubr5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24986 Ubr5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ubr5 NCBI NCBI:51366