TNFAIP2 - TNF alpha induced protein 2 Gene

Also Known as B94; EXOC3L3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7127

About TNFAIP2

Cytogenetic location: 14q32.32 Genomic coordinates (GRCh38): 14:103,121,469-103,137,439 (from NCBI)

This gene has 11 transcripts (splice variants), 271 orthologues and 4 paralogues. Ubiquitous expression in urinary bladder (RPKM 54.5), spleen (RPKM 53.6) and 22 other tissues.

Summary

This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]

TNFAIP2 Products (3)

mRNA Protein Name
NM_001371220.1 NP_001358149.1 tumor necrosis factor alpha-induced protein 2 isoform 2
NM_001371221.1 NP_001358150.1 tumor necrosis factor alpha-induced protein 2 isoform 2
NM_006291.4 NP_006282.2 tumor necrosis factor alpha-induced protein 2 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNFAIP2 Protein Structure

Sec6

Sec6: Exocyst complex component Sec6 (123 - 650)

  • 0
  • 200
  • 400
  • 600
  • 654 a.a.
Protein Preferred Names Protein Names

tumor necrosis factor alpha-induced protein 2

  • exocyst complex component 3-like 3

TNFAIP2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P811194 TNFAIP2 Antibody WB, IHC-P, ICC/IF Human, Mouse, Rat
HY-P89992 TNFα-IP 2 Antibody (YA9336) WB, ICC/IF, IF-Tissue, IP, ELISA human, mouse, rat

Related Diseases

Diseases Alias
Acute Promyelocytic Leukemia

  • Leukemia, Acute Promyelocytic

  • Acute Myeloblastic Leukemia Type 3

  • Aml M3

  • APL

  • Leukemia, Acute Promyelocytic, Somatic

  • Aml With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Apml

  • Acute Myeloblastic Leukemia 3

  • Acute Myeloid Leukemia With T(15

  • 17)(Q22

  • Q12)

  • (Pml/Raralpha) And Variants

  • Acute Myeloblastic Leukaemia Type 3

  • Acute Myeloid Leukaemia M3

  • Acute Myeloid Leukemia M3

  • Acute Promyelocytic Leukaemia

  • M3 Anll

  • Myeloid Leukemia, Acute, M3

  • Leukemia Promyelocytic Acute

  • Leukemia, Promyelocytic, Acute

  • Leukemia, Acute, Promyelocytic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14788 TNFAIP2 Human Pre-designed siRNA Set A Pre-designed Set ≥90.0% Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TNFAIP2 RGD RGD:1594556
Canis familiaris TNFAIP2 VGNC VGNC:47649
Bos taurus TNFAIP2 VGNC VGNC:53955
Felis catus TNFAIP2 VGNC VGNC:80817
Mus musculus TNFAIP2 MGD MGI:104960
Macaca mulatta TNFAIP2 VGNC VGNC:78579
Others TNFAIP2 NCBI