Sfpq - splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) Gene

Also Known as PSF; REP1; Gm12940; D4Ertd314e; 1110004P21Rik; 2810416M14Rik; 5730453G22Rik; 9030402K04Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 71514

Summary

Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including dendritic transport of messenger ribonucleoprotein complex; histone H3 deacetylation; and negative regulation of circadian rhythm. Acts upstream of or within cellular response to DNA damage stimulus; chromosome organization; and positive regulation of sister chromatid cohesion. Located in paraspeckles. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; lung mesenchyme; sensory organ; and testis. Orthologous to human SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Apr 2022]

Sfpq Products (1)

mRNA	Protein	Name
NM_023603.3	NP_076092.1	splicing factor, proline- and glutamine-rich

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables chromatin binding	IDA IDA: Inferred from direct assay	19389484	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	18495661	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21680841	MGI

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within DNA damage response	IMP IMP: Inferred from mutant phenotype	20813759	MGI
involved in chromatin remodeling	IMP IMP: Inferred from mutant phenotype	21680841	MGI
acts upstream of or within chromosome organization	IMP IMP: Inferred from mutant phenotype	20813759	MGI
involved in dendritic transport of messenger ribonucleoprotein complex	IDA IDA: Inferred from direct assay	15312650	MGI
involved in dendritic transport of messenger ribonucleoprotein complex	IMP IMP: Inferred from mutant phenotype	15312650	MGI
involved in negative regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	22966205	MGI
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	21680841	MGI
involved in negative regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	21680841	MGI
acts upstream of or within positive regulation of sister chromatid cohesion	IMP IMP: Inferred from mutant phenotype	20813759	MGI
acts upstream of or within regulation of cell cycle	IMP IMP: Inferred from mutant phenotype	20813759	MGI
involved in regulation of circadian rhythm	IMP IMP: Inferred from mutant phenotype	22966205	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of RNA polymerase II transcription regulator complex	IDA IDA: Inferred from direct assay	19389484	MGI
located in paraspeckles	IDA IDA: Inferred from direct assay	21444682	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
splicing factor, proline- and glutamine-rich	DNA-binding p52/p100 complex, 100 kDa subunit PTB-associated splicing factor polypyrimidine tract-binding protein-associated-splicing factor

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12770	SFPQ Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22321	Sfpq Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28843	Sfpq Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sfpq	NCBI	NCBI:6421